Application | Comment | Organism |
---|---|---|
synthesis | improved synthesis of 3-functionalized cephalosporins by enzyme in polyethylene glycol-ammonium sulfate aqueous two-phase systems. Best results are achieved using PEG 600, 80% in water, equilibrated with 4 M ammonium sulfate. Acylation product is completely partitioned in the PEG phase, whereas the substrates maintain a suitable concentration in the enzyme environment. Use for synthesis of cefamandole and cefonicid | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-aminocephalosporanic acid + (R)-mandelic acid | - |
Escherichia coli | 7-[(1-hydroxy-1-phenyl)-acetamido]-3-acetoxymethyl-D3-cephem-4-carboxylic acid | - |
? |