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Literature summary for 3.5.1.108 extracted from
- Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNFr inhibitors: a multiscreening approach (2007), J. Chem. Inf. Model., 47, 1188-1195.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-isopropyl-4-oxobutanamide | - |
Pseudomonas aeruginosa |  |
| (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide | - |
Pseudomonas aeruginosa | |
| (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide | - |
Pseudomonas aeruginosa | |
| (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide | - |
Pseudomonas aeruginosa | |
| (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide | - |
Pseudomonas aeruginosa | |
| 2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3,4-bis(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-N-hydroxyacetamide | - |
Pseudomonas aeruginosa | |
| 2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-fluoro-4-(3-methylbenzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide | - |
Pseudomonas aeruginosa | |
| 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide | - |
Pseudomonas aeruginosa | |
| 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide | - |
Pseudomonas aeruginosa | |
| 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-propyl-4,5-dihydroisoxazole-5-carboxamide | - |
Pseudomonas aeruginosa | |
| 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-N-methyl-4,5-dihydroisoxazole-5-carboxamide | - |
Pseudomonas aeruginosa | |
| 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-oxobutanoic acid | - |
Pseudomonas aeruginosa | |
| 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4-oxobutanamide | - |
Pseudomonas aeruginosa | |
| 4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide | - |
Pseudomonas aeruginosa | |
| 4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide | - |
Pseudomonas aeruginosa | |
| N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
| N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide | - |
Pseudomonas aeruginosa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| deacetylase LpxC | - |
Pseudomonas aeruginosa |
| LpxC | - |
Pseudomonas aeruginosa |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000162 | - |
- |
Pseudomonas aeruginosa | 2-(3,4-bis(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.000251 | - |
- |
Pseudomonas aeruginosa | 2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.000282 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.000355 | - |
- |
Pseudomonas aeruginosa | 2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.000501 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.000562 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.000851 | - |
- |
Pseudomonas aeruginosa | 2-(3-fluoro-4-(3-methylbenzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.000955 | - |
- |
Pseudomonas aeruginosa | 2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.001 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.001 | - |
- |
Pseudomonas aeruginosa | 2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.0012 | - |
- |
Pseudomonas aeruginosa | 2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00132 | - |
- |
Pseudomonas aeruginosa | 2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00159 | - |
- |
Pseudomonas aeruginosa | 2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00223 | - |
- |
Pseudomonas aeruginosa | 2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00251 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.00331 | - |
- |
Pseudomonas aeruginosa | 2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00398 | - |
- |
Pseudomonas aeruginosa | 4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide | |
| 0.00427 | - |
- |
Pseudomonas aeruginosa | 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-oxobutanoic acid | |
| 0.00427 | - |
- |
Pseudomonas aeruginosa | 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-N-methyl-4,5-dihydroisoxazole-5-carboxamide | |
| 0.00501 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.00501 | - |
- |
Pseudomonas aeruginosa | 2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00501 | - |
- |
Pseudomonas aeruginosa | 2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00562 | - |
- |
Pseudomonas aeruginosa | 2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00562 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.00603 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.00603 | - |
- |
Pseudomonas aeruginosa | 2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00661 | - |
- |
Pseudomonas aeruginosa | 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-propyl-4,5-dihydroisoxazole-5-carboxamide | |
| 0.007413 | - |
- |
Pseudomonas aeruginosa | 2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.00759 | - |
- |
Pseudomonas aeruginosa | 4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide | |
| 0.00794 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.00891 | - |
- |
Pseudomonas aeruginosa | (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide | |
| 0.00891 | - |
- |
Pseudomonas aeruginosa | (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide | |
| 0.00912 | - |
- |
Pseudomonas aeruginosa | 2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.01 | - |
- |
Pseudomonas aeruginosa | 2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.01 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)-4,5-dihydrooxazole-4-carboxamide | |
| 0.012 | - |
- |
Pseudomonas aeruginosa | 2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.0129 | - |
- |
Pseudomonas aeruginosa | N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide | |
| 0.0138 | - |
- |
Pseudomonas aeruginosa | 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide | |
| 0.0148 | - |
- |
Pseudomonas aeruginosa | 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4-oxobutanamide | |
| 0.0162 | - |
- |
Pseudomonas aeruginosa | 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid | |
| 0.0162 | - |
- |
Pseudomonas aeruginosa | (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide | |
| 0.0182 | - |
- |
Pseudomonas aeruginosa | 2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.0204 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide | |
| 0.0204 | - |
- |
Pseudomonas aeruginosa | 2-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-N-hydroxyacetamide | |
| 0.0229 | - |
- |
Pseudomonas aeruginosa | (S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide | |
| 0.0251 | - |
- |
Pseudomonas aeruginosa | 2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.0263 | - |
- |
Pseudomonas aeruginosa | 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide | |
| 0.0302 | - |
- |
Pseudomonas aeruginosa | 2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.0389 | - |
- |
Pseudomonas aeruginosa | N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide | |
| 0.0468 | - |
- |
Pseudomonas aeruginosa | 2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | |
| 0.0589 | - |
- |
Pseudomonas aeruginosa | 2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide | |
| 0.138 | - |
- |
Pseudomonas aeruginosa | (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-isopropyl-4-oxobutanamide | |
| 0.479 | - |
- |
Pseudomonas aeruginosa | 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide | |
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