Organism | UniProt | Comment | Textmining |
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Escherichia coli | - |
- |
- |
General Information | Comment | Organism |
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metabolism | the membrane-anchored FtsH protease is essential in Escherichia coli as it adjusts the cellular amount of LpxC, the key enzyme in lipopolysaccharide biosynthesis. Both accumulation and depletion of LpxC are toxic to Escherichia coli. By continuous proteolysis of LpxC, FtsH maintains a low concentration of LpxC and, hence, the proper equilibrium between lipopolysaccharide and phospholipids. The C terminus of LpxC is required for turnover. Detailed mutational analysis revealed six non-polar residues in the C terminus of LpxC that are critical for degradation | Escherichia coli |