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Literature summary for 3.5.1.103 extracted from
- Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis (2003), Microbiology, 149, 1341-1349.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mycolicibacterium smegmatis | MshB activity as a control point regulating mycothiol production | ? | - |
? |  |
| additional information | Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | MshB activity as a control point regulating mycothiol production | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycolicibacterium smegmatis | - |
- |
- |
| Mycolicibacterium smegmatis | A0R2I7 | - |
- |
| Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | A0R2I7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | MshB activity as a control point regulating mycothiol production | Mycolicibacterium smegmatis | ? | - |
? | |
| additional information | MshB activity as a control point regulating mycothiol production | Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MshB | - |
Mycolicibacterium smegmatis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | disruption of mshB in Mycobacterium smegmatis results in decreased production of mycothiol (510% of the parent strain mc2155) but does not abolish mycothiol synthesis completely. Complementation of the MshB2 mutants with the mshB gene results in increased mycothiol production towards the exponential and stationary phases of the bacterial growth cycle. The results suggest that another enzyme is capable of mycothiol biosynthesis by providing N-acetylglucosaminylinositol deacetylation activity in the absence of MshB | Mycolicibacterium smegmatis |
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