Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzyl 2-deoxy-2-acetamido-1-thio-beta-D-glucopyranoside | 0.5 mM, 13% inhibition | Mycobacterium tuberculosis | |
cyclohexyl (2''R),(2''S)-3,3''-anhydro-2-deoxy-2-C-(2'',3''-dihydroxypropyl)-alpha-D-glucopyranoside | 0.5 mM, 6.6% inhibition | Mycobacterium tuberculosis | |
cyclohexyl 2-deoxy-2-C-(2'',3''-epoxypropyl)-alpha-D-glucopyranoside | 0.5 mM, 19.7% inhibition | Mycobacterium tuberculosis | |
cyclohexyl 2-deoxy-2-C-(2''-hydroxypropyl)-alpha-D-glucopyranoside | 0.5 mM, 11.4% inhibition | Mycobacterium tuberculosis | |
cyclohexyl 2-deoxy-2-C-(2''-oxopropyl)-a-D-glucopyranoside | 0.5 mM, 6.7% inhibition | Mycobacterium tuberculosis | |
cyclohexyl-2-chloroacetamido-2-deoxy-1-thio-alpha-D-glucopyranoside | 0.5 mM, 15% inhibition | Mycobacterium tuberculosis | |
phenyl-2-acetamido-2-deoxy-1-thio-alpha-D-glucopyranoside | 0.5 mM, 6% inhibition | Mycobacterium tuberculosis | |
phenyl-2-deoxy-2-acetamido-1-thio-beta-D-glucopyranoside | 0.5 mM, 15% inhibition | Mycobacterium tuberculosis | |
phenyl-2-deoxy-2-[3'-(8''-hydroxy-3''-methyl-1'',4''-dioxo-1'',4''-dihydronaphthalen-2''-yl)butanamido]-1-thio-alpha-D-glucopyranoside | 0.5 mM, 81.6% inhibition | Mycobacterium tuberculosis | |
phenyl-2-deoxy-2-[3'-(8''-hydroxy-3''-methyl-1'',4''-dioxo-1'',4''-dihydronaphthalen-2''-yl)pentanamido]-1-thio-alpha-D-glucopyranoside | 0.5 mM, 81.4% inhibition | Mycobacterium tuberculosis | |
phenyl-2-deoxy-2-[3'-(8''-hydroxy-3''-methyl-1'',4''-dioxo-1'',4''-dihydronaphthalen-2''-yl)propanamido]-1-thio-alpha-D-glucopyranoside | 0.5 mM, 57.4% inhibition | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.348 | - |
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | pH 7.5, 37°C | Mycobacterium tuberculosis | |
1.695 | - |
phenyl-2-acetamido-2-deoxy-1-thio-alpha-D-glucopyranoside | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O | Mycobacterium tuberculosis | biosynthesis of mycothiol and detoxification of xenobiotics as their mycothiol-S-conjugates | 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O | - |
Mycobacterium tuberculosis | 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate | - |
? | |
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O | biosynthesis of mycothiol and detoxification of xenobiotics as their mycothiol-S-conjugates | Mycobacterium tuberculosis | 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + acetate | - |
? | |
cyclohexyl-2-acetamido-2-deoxy-1-thio-alpha-D-glucopyranoside + H2O | 6% of the activity with 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | Mycobacterium tuberculosis | cyclohexyl-2-amino-2-deoxy-1-thio-alpha-D-glucopyranoside + acetate | - |
? | |
cyclohexyl-2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O | 6% of the activity with 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | Mycobacterium tuberculosis | cyclohexyl-2-amino-2-deoxy-alpha-D-glucopyranoside + acetate | - |
? | |
phenyl 2-acetamido-2-deoxy-1-thio-alpha-D-glucopyranoside + H2O | - |
Mycobacterium tuberculosis | phenyl 2-amino-2-deoxy-1-thio-alpha-D-glucopyranoside + acetate | - |
? | |
phenyl 2-acetamido-2-deoxy-1-thio-alpha-D-glucopyranoside + H2O | 25% of the activity with 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | Mycobacterium tuberculosis | phenyl 2-amino-2-deoxy-1-thio-alpha-D-glucopyranoside + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GlcNAc-Ins-deacetylase | - |
Mycobacterium tuberculosis |
MshB | - |
Mycobacterium tuberculosis |
N-acetylglucosaminylinositol-deacetylase | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.12 | - |
phenyl-2-acetamido-2-deoxy-1-thio-alpha-D-glucopyranoside | pH 7.5, 37°C | Mycobacterium tuberculosis | |
0.24 | - |
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | pH 7.5, 37°C | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mycobacterium tuberculosis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
phenyl-2-acetamido-2-deoxy-1-thio-alpha-D-glucopyranoside | pH 7.5, 37°C | Mycobacterium tuberculosis | |
0.68 | - |
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol | pH 7.5, 37°C | Mycobacterium tuberculosis |