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Literature summary for 3.5.1.1 extracted from

  • Scotti, C.; Sommi, P.; Pasquetto, M.V.; Cappelletti, D.; Stivala, S.; Mignosi, P.; Savio, M.; Chiarelli, L.R.; Valentini, G.; Bolanos-Garcia, V.M.; Merrell, D.S.; Franchini, S.; Verona, M.L.; Bolis, C.; Solcia, E.; Manca, R.; Franciotta, D.; Casasco, A.; Filipazzi, P.; Zardini, E.; Vannini, V.
    Cell-cycle inhibition by Helicobacter pylori L-asparaginase (2010), PLoS ONE, 5, e13892.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
5-Diazo-4-oxo-L-norvaline inhibits L-asparaginase activity and affects broth culture filtrate inhibition of the cell cycle Helicobacter pylori

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 4 * 37000, SDS-PAGE Helicobacter pylori
144000
-
 PAGE Helicobacter pylori

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-

Subunits

Subunits Comment Organism
tetramer 4 * 37000, SDS-PAGE Helicobacter pylori

General Information

General Information Comment Organism
physiological function Helicobacter pylori L-asparaginase is able to inhibit the cell-cycle of fibroblasts and gastric cell lines. Interference with cell-cycle in vitro depends on cell genotype and is related to the expression levels of the concurrent enzyme asparagine synthetase Helicobacter pylori