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Literature summary for 3.5.1.1 extracted from
- Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice (2008), J. Nutr., 138, 338-343.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | asparaginase is used in the treatment of acute lymphoblastic leukemia. It depletes plasma asparagine and glutamine, killing leukemic lymphoblasts but also causing immunosuppression. Asparaginase reduces maturing populations of normal B and T cells in thymus, bone marrow, and spleen of mice. Oral consumption of alanyl-glutamine mitigates metabolic stress in spleen, supporting the peripheral immune system and cell-mediated immunity during asparaginase chemotherapy | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
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Release 2023.1 (January 2023)
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