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Literature summary for 3.5.1.1 extracted from

  • Reinert, R.B.; Oberle, L.M.; Wek, S.A.; Bunpo, P.; Wang, X.P.; Mileva, I.; Goodwin, L.O.; Aldrich, C.J.; Durden, D.L.; McNurlan, M.A.; Wek, R.C.; Anthony, T.G.
    Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase (2006), J. Biol. Chem., 281, 31222-31233.
    View publication on PubMed
Search for more literature for 3.5.1.1

Application

Application Comment Organism
medicine L-asparaginase is important in the induction regimen for treating human acute lymphoblastic leukemia, cytotoxic complications are clinically significant problems lacking mechanistic insight, the enzyme is used in the treatment of both pediatric and adult forms of acute lymphoblastic leukemia, ALL Escherichia coli
medicine L-asparaginase is important in the induction regimen for treating human acute lymphoblastic leukemia, cytotoxic complications are clinically significant problems lacking mechanistic insight, the enzyme is used in the treatment of both pediatric andadult forms of acute lymphoblastic leukemia, ALL Wolinella succinogenes

Protein Variants

Protein Variants Comment Organism
additional information applicated to mice, the enzyme abolishes serum asparagine and glutamine, and reduces protein synthesis in liver, and spleen, but not in pancreas via increase dephosphorylation of the translation factor eIF2, overview Escherichia coli
additional information applicated to mice, the enzyme abolishes serum asparagine, but not glutamine, the enzyme does not alter protein synthesis, overview Wolinella succinogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-asparagine + H2O Escherichia coli
-
 L-aspartate + NH3
-
 ?
L-asparagine + H2O Wolinella succinogenes
-
 L-aspartate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Wolinella succinogenes
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Wolinella succinogenes
further purification of the commercial preparation by gel filtration to remove endotoxin Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-asparagine + H2O
-
 Escherichia coli L-aspartate + NH3
-
 ?
L-asparagine + H2O
-
 Wolinella succinogenes L-aspartate + NH3
-
 ?

Synonyms

Synonyms Comment Organism
L-asparaginase
-
 Escherichia coli
L-asparaginase
-
 Wolinella succinogenes