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Literature summary for 3.4.99.B1 extracted from
- RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments (2011), Proc. Natl. Acad. Sci. USA, 108, 8862-8866.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P57791 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retina | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphodiesterase 6 + H2O | - |
Mus musculus | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ras-converting enzyme 1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | retinal development proceeds normally in the absence of RAS-converting enzyme 1 (Rce1), but photoreceptor cells fail to respond to light and subsequently degenerate in a rapid fashion. Phosphodiesterase 6 is unable to be transported to the outer segments in Rce1-deficient photoreceptor cells | Mus musculus |
| physiological function | RCE1 is essential for the intracellular trafficking of phosphodiesterase 6 and survival of photoreceptor cells | Mus musculus |
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Release 2023.1 (January 2023)
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