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Literature summary for 3.4.99.B1 extracted from

  • Otto, J.C.; Kim, E.; Young, S.G.; Casey, P.J.
    Cloning and characterization of a mammalian prenyl protein-specific protease (1999), J. Biol. Chem., 274, 8379-8382.
    View publication on PubMed
Search for more literature for 3.4.99.B1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RPI farnesyl-peptide analogue, 0.000005 mM, 50% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
 Ki-Ras farnesylated or geranylgeranylated Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane multiple predicted transmembrane domains Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y256
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl-Ha-Ras-CaaX + H2O
-
 Homo sapiens farnesyl-Ha-Ras-C + aaX
-
 ?
farnesyl-Ki-Ras-CaaX + H2O specific for prenylated proteins containing a C-terminal CaaX motif Homo sapiens farnesyl-Ki-Ras-C + aaX
-
 ?
farnesyl-N-Ras-CaaX + H2O
-
 Homo sapiens farnesyl-N-Ras-C + aaX
-
 ?
G-gamma1-CaaX + H2O
-
 Homo sapiens G-gamma1-C + aaX
-
 ?
geranylgeranyl-Ki-Ras-CaaX + H2O
-
 Homo sapiens geranylgeranyl-Ki-Ras-C + aaX
-
 ?
geranylgeranyl-Rab1b-CaaX + H2O
-
 Homo sapiens geranylgeranyl-Rab1b-C + aaX
-
 ?
Ki-Ras + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
hRCE1
-
 Homo sapiens