Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bortezomib | - |
Homo sapiens | |
carfilzomib | - |
Homo sapiens | |
marizomib | - |
Homo sapiens | |
MG-132 | - |
Homo sapiens | |
N-(tert-butoxycarbonyl)-L-phenylalanyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | 60.06% inhibition at 0.01 mM | Homo sapiens | |
N-(tert-butoxycarbonyl)-O-methyl-L-tyrosyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | 89.7% inhibition at 0.01 mM | Homo sapiens | |
N-(tert-butoxycarbonyl)-O-methyl-L-tyrosyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | 69.7% inhibition at 0.01 mM | Homo sapiens | |
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | 58.5% inhibition at 0.01 mM | Homo sapiens | |
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | 73.4% inhibition at 0.01 mM | Homo sapiens | |
N-[(benzyloxy)carbonyl]-L-phenylalanyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | 82.2% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | 7.7% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | 16.5% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-O-methyl-L-tyrosinamide | 73% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(2S)-2-[2-(tert-butoxycarbonyl)hydrazinyl]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | - |
Homo sapiens | |
Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-(4-methoxyphenyl)butanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | 84.8% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | 47.5% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | 67.1% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | 14.9% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | 5.7% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | 13.6% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-O-methyl-L-tyrosinamide | 60.5% inhibition at 0.01 mM | Homo sapiens | |
Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | 36.4% inhibition at 0.01 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-375 cell | - |
Homo sapiens | - |
A-549 cell | - |
Homo sapiens | - |
BGC-823 cell | - |
Homo sapiens | - |
DU-145 cell | - |
Homo sapiens | - |
HCT-8 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-LLVY-aminoluciferin + H2O | - |
Homo sapiens | ? | - |
? | |
Z-LRR-aminoluciferin + H2O | - |
Homo sapiens | ? | - |
? | |
Z-nLPnLD-aminoluciferin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
20S proteasome | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000373 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | MG-132 | |
0.00164 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | N-(tert-butoxycarbonyl)-O-methyl-L-tyrosyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | |
0.00262 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | N-[(benzyloxy)carbonyl]-L-phenylalanyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | |
0.00327 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-(4-methoxyphenyl)butanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | |
0.00585 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | |
0.00601 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-O-methyl-L-tyrosinamide | |
0.00642 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | |
0.00682 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-O-methyl-L-tyrosinamide | |
0.00756 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | |
0.00785 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(2S)-2-[2-(tert-butoxycarbonyl)hydrazinyl]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | |
0.00815 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | N-(tert-butoxycarbonyl)-O-methyl-L-tyrosyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | |
0.00839 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | |
0.00942 | - |
in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | N-(tert-butoxycarbonyl)-L-phenylalanyl-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | |
0.01 | - |
IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | |
0.01 | - |
IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-(tert-butoxycarbonyl)-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | |
0.01 | - |
IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(2S)-2-[[(benzyloxy)carbonyl]amino]-4-phenylbutanoyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide | |
0.01 | - |
IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide | |
0.01 | - |
IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]-L-tyrosinamide | |
0.01 | - |
IC50 above 0.01 mM, in 10 mM HEPES (pH 7.6), at 37°C | Homo sapiens | Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-[[(2S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-O-methyl-L-tyrosinamide |