Application | Comment | Organism |
---|---|---|
additional information | peptide splicing is an intrinsic additional catalytic property of the proteasome, which may provide a qualitative peptide pool for immune selection | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | immortalized with Epstein Barr virus | Homo sapiens | - |
lymphoblast | - |
Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | development of SpliceMet: a method that combines combinatorial computations with mass spectrometric analyses of proteasome-generated spliced peptides, for analysis of peptides, presented by MHC class I molecules on the cell surface, in a manner independent of cytotoxic T lymphocytes, kinetics, detailed overview | Homo sapiens |
physiological function | the 20S proteasome, which is the major proteolytic enzyme of the cell, is responsible for the generation of antigenic peptides derived from endogenously expressed foreign or aberrant protein molecules. The proteasome-generated spliced peptides are presented by MHC class I molecules to the outside world so that they can be specifically recognised by cytotoxic T lymphocytes at the cell surface. Peptide splicing is an intrinsic additional catalytic property of the proteasome | Homo sapiens |