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Literature summary for 3.4.25.1 extracted from
- Nuclear effects of ethanol-induced proteasome inhibition in liver cells (2009), World J. Gastroenterol., 15, 1163-1167.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ethanol | ethanol-induced proteasome inhibition in liver cells | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 20S proteasome | - |
Homo sapiens |
| proteasome | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the ubiquitin-proteasome pathway plays an important role in a variety of cellular functions, primarily via its proteolytic activity, and is one of the vital pathways in the cell that becomes dysfunctional as a result of chronic ethanol consumption. The inhibition of proteasome activity in the nucleus is therefore etiologically involved in the accumulation of damaged proteins in the nucleus, and in the deregulation of transcription | Homo sapiens |
| physiological function | the ubiquitin-proteasome pathway is essential for promoting the exchange of transcriptional factors on chromatin | Homo sapiens |
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