Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | gold(I)- and gold(III)-compound-mediated proteasome inhibition and cell death induction are completely reversed by the addition of reducing agents, e.g. dithiothreitol or N-acetyl-L-cysteine | Homo sapiens | |
additional information | gold(I)- and gold(III)-compound-mediated proteasome inhibition and cell death induction are completely reversed by the addition of reducing agents, e.g. dithiothreitol or N-acetyl-L-cysteine | Oryctolagus cuniculus | |
[Au(ESDT)]2 | i.e. AUL15, a gold(I)-dithiocarbamato species, inhibits the chymotrypsin-like activity of purified 20S proteasome and 26S proteasome in breast cancer cells | Homo sapiens | |
[Au(ESDT)]2 | i.e. AUL15, a gold(I)-dithiocarbamato species, inhibits the chymotrypsin-like activity of purified 20S proteasome | Oryctolagus cuniculus | |
[AuBr2(ESDT)] | i.e. AUL12, a gold(III)-dithiocarbamato species, inhibits the chymotrypsin-like activity of purified 20S proteasome and 26S proteasome in breast cancer cells | Homo sapiens | |
[AuBr2(ESDT)] | i.e. AUL12, a gold(III)-dithiocarbamato species, inhibits the chymotrypsin-like activity of purified 20S proteasome | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | purified 20S proteasome | Oryctolagus cuniculus | - |
MDA-MB-231 cell | breast cancer cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O | chymotrypsin-like proteasome activity | Homo sapiens | N-succinyl-LLVY + 7-amino-4-methylcoumarin | - |
? | |
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O | chymotrypsin-like proteasome activity | Oryctolagus cuniculus | N-succinyl-LLVY + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
20S proteasome | - |
Homo sapiens |
20S proteasome | - |
Oryctolagus cuniculus |
26S proteasome | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Oryctolagus cuniculus |
General Information | Comment | Organism |
---|---|---|
additional information | inhibition of the proteasomes by gold complexes results in accumulation of ubiquitinated proteins and proteasome target proteins, and induction of cell death, but at significantly different levels | Homo sapiens |