Application | Comment | Organism |
---|---|---|
medicine | possible use of proteasome inhibitors for immunosuppression | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bortezomib | activates the mitochondrial pathway of apoptosis in activated CD4+ T cells by disrupting the equilibrium of pro-apoptotic and anti-apoptotic proteins at the outer mitochondrial membrane and by inducing the generation of reactive oxygen species | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | - |
Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
proteasome | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | inhibition of the proteolytic activity of the proteasome induces apoptosis and suppresses essential functions of activated human CD4+ T cells, and proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells, detailed mechanisms of apoptosis, overview | Homo sapiens |