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Literature summary for 3.4.25.1 extracted from

  • Millet, V.; Moiola, C.P.; Pasquini, J.M.; Soto, E.F.; Pasquini, L.A.
    Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination (2009), Exp. Neurol., 217, 282-296.
    View publication on PubMed
Search for more literature for 3.4.25.1

Inhibitors

Inhibitors Comment Organism Structure
lactacystin specific inhibitor of the proteasome, partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
oligodendroglial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
 ?
Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Boc-Leu-Ser-Thr-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
proteasome
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus

General Information

General Information Comment Organism
additional information a decrease in proteasome activity induced by the injection of lactacystin in the corpus callosum in the remyelination process that normally occurs after cuprizone-induced demyelination markedly improves the remyelination process. It also attenuates the activation of NFkappaB and the recruitment of microglia and astrocytes, thus helping in the recovery of the mitochondrial respiratory chain activities that are affected by cuprizone treatment Mus musculus
physiological function physiological effects of partial inhibition of proteolytic activities of the proteasome, overview Mus musculus