Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lactacystin | a specific proteasome inhibitor | Mus musculus | |
additional information | no direct inhibition of the proteasome by LY294002, but treatment with phosphatidylinositol-3 kinase inhibitors LY294002 or wortmannin, leads to increased levels of PS1/gamma-secretase components through an inhibitory effect on their degradation. Phosphatidylinositol-3 kinase inhibition may trigger the multiple mono-ubiquitination of PS1, which precludes the degradation of PS1/gamma-secretase through the proteasomal pathway, overview | Mus musculus | |
syringolin A | a tripeptide derivative, from Pseudomonas putida pv. syringae B728a, consisting of an N-terminal valine followed by the two non-proteinogenic amino acids 3,4-dehydrolysine and 5-methyl-4-amino-2-hexenoic acid, the latter two forming a twelve-membered macrolactam ring, irreversibly inhibits the eukaryotic proteasome, mechanism, overview. The biosynthesis of the compound involves genes sylA-sylE, structure, overview | Phaseolus vulgaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
PS1/gamma-secretase complex component + H2O | Mus musculus | gamma-secretase components are PS1, nicastrin, Pen-2, and Aph-1. Degradation of the complex components involves the proteasome, but regulation of their activity involves the PI3K/Akt pathway, overview. PS1/gamma-secretase is involved in the activation of phosphatidylinositol-3 kinase/Akt pathway, and is responsible for the intramembranous cleavage of various type-I membrane proteins. PS1/gamma-secretase is also deeply involved in the production of amyloid beta protein | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
ICR mice | - |
Phaseolus vulgaris | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebral cortex | from fetal ICR mice | Mus musculus | - |
neuron | cortical neurons in primary culture from fetal ICR mice cerebral cortex | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
PS1/gamma-secretase complex component + H2O | gamma-secretase components are PS1, nicastrin, Pen-2, and Aph-1. Degradation of the complex components involves the proteasome, but regulation of their activity involves the PI3K/Akt pathway, overview. PS1/gamma-secretase is involved in the activation of phosphatidylinositol-3 kinase/Akt pathway, and is responsible for the intramembranous cleavage of various type-I membrane proteins. PS1/gamma-secretase is also deeply involved in the production of amyloid beta protein | Mus musculus | ? | - |
? | |
PS1/gamma-secretase complex component + H2O | gamma-secretase components are PS1, nicastrin, Pen-2, and Aph-1 | Mus musculus | ? | - |
? | |
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | 7-amino-4-methylcoumarin + Suc-Leu-Leu-Val-Tyr | - |
? |
Synonyms | Comment | Organism |
---|---|---|
proteasome | - |
Phaseolus vulgaris |
proteasome | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |