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Literature summary for 3.4.25.1 extracted from

  • Aoyagi, N.; Uemura, K.; Kuzuya, A.; Kihara, T.; Kawamata, J.; Shimohama, S.; Kinoshita, A.; Takahashi, R.
    PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity (2010), Biochem. Biophys. Res. Commun., 391, 1240-1245.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
lactacystin a specific proteasome inhibitor Mus musculus
additional information no direct inhibition of the proteasome by LY294002, but treatment with phosphatidylinositol-3 kinase inhibitors LY294002 or wortmannin, leads to increased levels of PS1/gamma-secretase components through an inhibitory effect on their degradation. Phosphatidylinositol-3 kinase inhibition may trigger the multiple mono-ubiquitination of PS1, which precludes the degradation of PS1/gamma-secretase through the proteasomal pathway, overview Mus musculus
syringolin A a tripeptide derivative, from Pseudomonas putida pv. syringae B728a, consisting of an N-terminal valine followed by the two non-proteinogenic amino acids 3,4-dehydrolysine and 5-methyl-4-amino-2-hexenoic acid, the latter two forming a twelve-membered macrolactam ring, irreversibly inhibits the eukaryotic proteasome, mechanism, overview. The biosynthesis of the compound involves genes sylA-sylE, structure, overview Phaseolus vulgaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
PS1/gamma-secretase complex component + H2O Mus musculus gamma-secretase components are PS1, nicastrin, Pen-2, and Aph-1. Degradation of the complex components involves the proteasome, but regulation of their activity involves the PI3K/Akt pathway, overview. PS1/gamma-secretase is involved in the activation of phosphatidylinositol-3 kinase/Akt pathway, and is responsible for the intramembranous cleavage of various type-I membrane proteins. PS1/gamma-secretase is also deeply involved in the production of amyloid beta protein ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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ICR mice
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Phaseolus vulgaris
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex from fetal ICR mice Mus musculus
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neuron cortical neurons in primary culture from fetal ICR mice cerebral cortex Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
PS1/gamma-secretase complex component + H2O gamma-secretase components are PS1, nicastrin, Pen-2, and Aph-1. Degradation of the complex components involves the proteasome, but regulation of their activity involves the PI3K/Akt pathway, overview. PS1/gamma-secretase is involved in the activation of phosphatidylinositol-3 kinase/Akt pathway, and is responsible for the intramembranous cleavage of various type-I membrane proteins. PS1/gamma-secretase is also deeply involved in the production of amyloid beta protein Mus musculus ?
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?
PS1/gamma-secretase complex component + H2O gamma-secretase components are PS1, nicastrin, Pen-2, and Aph-1 Mus musculus ?
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?
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
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Mus musculus 7-amino-4-methylcoumarin + Suc-Leu-Leu-Val-Tyr
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?

Synonyms

Synonyms Comment Organism
proteasome
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Phaseolus vulgaris
proteasome
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Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus