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Literature summary for 3.4.24.B8 extracted from

  • Kim, E.; Yamashita, M.; Nakanishi, T.; Park, K.E.; Kimura, M.; Kashiwabara, S.; Baba, T.
    Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization (2006), J. Biol. Chem., 281, 5634-5639.
    View publication on PubMed

Application

Application Comment Organism
medicine crucial role of ADAM1b/ADAM2 fertilin not in the sperm/egg fusion, but in the appearance of these two ADAMs on the sperm surface Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information ADAM1b deficient mice, no significant defect in sperm functions such as migration from the uterus into oviduct, binding to egg zona pellucida, and fusion with zona pellucida-free eggs, but severe reduction of ADAM2 on cell surface Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sperm
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
ADAM1b
-
Mus musculus