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Literature summary for 3.4.24.B8 extracted from
- Characterization of the binding of recombinant mouse sperm fertilin alpha subunit to mouse eggs: evidence for function as a cell adhesion molecule in sperm-egg binding (1997), Dev. Biol., 187, 94-106.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of subunit alpha as fusion protein with maltose binding protein in Escherichia coli DH5alpha | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | binding to the egg is reduced by treatment with chymotrypsin | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | on the cell surface | Mus musculus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates, required | Mus musculus |  |
| Mg2+ | activates | Mus musculus | |
| Mn2+ | activates | Mus musculus | |
| additional information | divalent cations are required for membrane fusion | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme mediates the cell-cell membrane fusion of egg and sperm | ? | - |
? | |
| proteins + H2O | Mus musculus | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| proteolytic degradation of proteins | mechanism | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| sperm | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme mediates the cell-cell membrane fusion of egg and sperm | Mus musculus | ? | - |
? | |
| proteins + H2O | - |
Mus musculus | peptides | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Mus musculus |
| More | the alpha subunit contains a putative fusion peptide, beta subunit contains a soluble disintegrin ligand | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| fertilin | - |
Mus musculus |
| M12.201 | Merops-ID | Mus musculus |
| PH-30 | - |
Mus musculus |
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