Literature summary for 3.4.24.B7 extracted from

Xu, X.; Ma, J.; Li, C.; Zhao, W.; Xu, Y.
Regulation of chondrosarcoma invasion by MMP26 (2015), Tumour Biol., 36, 365-369.

Search for more literature for 3.4.24.B7

Application

Application	Comment	Organism
medicine	matrix metalloproteinase MMP26 level is significantly higher in the resected chondrosarcoma than in the adjacent healthy chondral tissue from patients. Overexpression of MMP26 in SW-1353 cells increases cell invasiveness, while inhibition of MMP26 decreases cell invasiveness. Inhibition of Wnt signaling significantly decreases the effect of MMP26 on cancer cell invasion. A strong correlation is detected between MMP26 levels and the ratio of phosphorylated/total beta-catenin in chondrosarcoma from the patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NRE1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SW-1353 cell	chondrosarcoma cell line	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	overexpression of MMP26 in SW-1353 chondrosarcoma cells increases cell invasiveness, while inhibition of MMP26 decreases cell invasiveness. Inhibition of Wnt signaling significantly decreases the effect of MMP26 on cancer cell invasion	Homo sapiens

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Release 2023.1 (January 2023)