Literature summary for 3.4.24.B7 extracted from

Yang, H.; Wang, Y.; Li, Y.; Zhang, L.; Deng, Y.; Qi, D.; Li, Y.; Li, W.
Roles of matrix metalloproteinase-26 in the growth, invasion and angiogenesis of breast cancer (2012), Oncol. Lett., 4, 832-836.

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Cloned(Commentary)

Cloned (Comment)	Organism
transfection of MCF-7 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NRE1	-	-

General Information

General Information	Comment	Organism
physiological function	MMP26-transfected MCF-7 cells demonstrate increased atypia, including unusual mitotic figures, glucogen pools and special lysosomes in the cytoplasm. The adherence and spreading ability of MMP26-transfected cells are significantly increased compared with cells in the control group. The migration and invasion ability of MMP26-transfected cells is dramatically accelerated compared with the control group, but markedly reduced in the presence of anti-MMP26 antibody. MMP26 also increases the malignant phenotype in vivo. The number of vessel branches and the total length of vessels induced by MMP26-transfected cells are significantly increased compared to those induced by nontransfected cells	Homo sapiens

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Release 2023.1 (January 2023)