Literature summary for 3.4.24.B7 extracted from

Ahokas, K.; Karjalainen-Lindsberg, M.L.; Sihvo, E.; Isaka, K.; Salo, J.; Saarialho-Kere, U.
Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer (2006), Tumour Biol., 27, 133-141.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
esophageal squamous cell carcinoma cell	33 out of 34 of the primary tumors express MMP-26. Most abundant expression concentrates in grade I-II tumors. In normal esophagus, the basal cells are usually negative for MMP-26, except for occasional basal cells at the top of epidermal papillae. MMP-26 is already upregulated in dysplasia. Tumor cells making contact with islets undergoing apoptosis show prominent MMP-26 staining, and inflammation upregulates MMP-26 expression. When the invasive islet escapes through the basement membrane, MMP-26 expression becomes abundant. The pushing border of the tumor only shows dispersed MMP-26 staining, and MMP-26 does not colocalize with proliferation or apoptosis. Neoplastic islands are often positive for MMP-26. In 2 out of 4 lymph nodes, MMP-26 is detected in metastatic tumor cells, where individual cancer cells expressed MMP-26 on the border of apoptotic areas non-neoplastic epithelium	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-26	-	Homo sapiens

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Release 2023.1 (January 2023)