Literature summary for 3.4.24.B7 extracted from

Yamamoto, H.; Vinitketkumnuen, A.; Adachi, Y.; Taniguchi, H.; Hirata, T.; Miyamoto, N.; Nosho, K.; Imsumran, A.; Fujita, M.; Hosokawa, M.; Hinoda, Y.; Imai, K.
Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma (2004), Carcinogenesis, 25, 2353-2360.

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Application

Application	Comment	Organism
medicine	expression of matrilysin-2 is significantly correlated with nuclear beta-catenin expression and MMP-9 expression. Patients with matrilysin-2-positive cancer have significantly shorter overall and disease-free survival periods than those with matrilysin-2 negative cancer. Matrilysin-2 expression retains its significant predictive value for overall and disease-free survival in multivariate analysis. Patients with concomitant expression of matrilysin-2 and MMP-9 have the worst prognosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
esophageal squamous cell carcinoma cell	overexpression in 24 of the 50 esophageal squamous cell carcinoma tissues. Overexpression is significantly correlated with depth of invasion, lymph node metastasis amd an advance in pathological tumor node metastasis stage	Homo sapiens	-
additional information	matrilysin-2 mRNA expression is undetectable or only faintly detected in non-tumor tissues	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
matrilysin-2	-	Homo sapiens
MMP-26	-	Homo sapiens

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Release 2023.1 (January 2023)