Application | Comment | Organism |
---|---|---|
medicine | matrix metalloproteinase-26 is a marker of melanomas and estrogen-dependent carcinomas | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of proenzyme MMP-26 in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG3340 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
proenzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha1-antitrypsin + H2O | Homo sapiens | MMP-26 by cleaving and inactivating the alpha1-antitrypsin serpin, operates as a unique functional link that regulates a coordinated interplay between Ser and metalloproteinases in estrogen-dependent neoplasm. Involvement of MMP-26 in inflammation and malignant progression of estrogen-dependent tumor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | autocatalytically activated in cells and tissues | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinantly expressed proenzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
IGROV-1 cell | - |
Homo sapiens | - |
Ishikawa cell | - |
Homo sapiens | - |
macrophage | matrix metalloproteinase-26 is associated with macrophages and polymorphonuclear leukocytes | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-435 cell | - |
Homo sapiens | - |
OVCAR-3 cell | - |
Homo sapiens | - |
OVCAR-4 cell | - |
Homo sapiens | - |
OVCAR-5 cell | - |
Homo sapiens | - |
OVCAR-8 cell | - |
Homo sapiens | - |
polymorphonuclear leukocyte | matrix metalloproteinase-26 is associated with macrophages and polymorphonuclear leukocytes | Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
ZR-75-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Gly-Leu-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
alpha1-antitrypsin + H2O | MMP-26 by cleaving and inactivating the alpha1-antitrypsin serpin, operates as a unique functional link that regulates a coordinated interplay between Ser and metalloproteinases in estrogen-dependent neoplasm. Involvement of MMP-26 in inflammation and malignant progression of estrogen-dependent tumor | Homo sapiens | ? | - |
? | |
alpha1-antitrypsin + H2O | the enzyme is highly efficient in cleaving the the serpin alpha1-antitrypsin at the positions Gln135-/-Leu136, Glu223-/-Val224, Phe376-/-Leu377, and Pro381-/-Met382 | Homo sapiens | ? | - |
? | |
additional information | the enzyme exhibits an unconventional PH81CGVPD Cys switch motif | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-26 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000015 | - |
AG3340 | - |
Homo sapiens |