Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | - |
Homo sapiens | |
(3S)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | - |
Homo sapiens | |
4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH | - |
Homo sapiens | |
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan | i.e. GM6001 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloproteinase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | two of the major autolytic sites are Leu49/-Thr50 and Ala75/-Leu76, which still left the cysteine switch sequence intact | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O | among the fluorescent peptide substrates analyzed, 7-amido-4-methylcoumaryl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 displays the highest specificity constant | Homo sapiens | (7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala + Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 | - |
? | |
alpha1-proteinase inhibitor + H2O | MMP-26 cleaves Phe352Leu353 and Pro357Met358 in the reactive loop of alpha1-proteinase inhibitor, probably rendering the substrate inactive | Homo sapiens | ? | - |
? | |
insulin-like growth factor-binding protein-1 + H2O | cleaves His140Val141 in insulin-like growth factor-binding protein-1, probably rendering the substrate inactive | Homo sapiens | ? | - |
? | |
peptide + H2O | the optimal cleavage motifs for MMP-26 are Lys-Pro-Ile(Leu)-Ser-/-Leu(Met)-Ile(Thr)-Ser(Ala)-Ser. The strongest preference is observed at the P1' and P2 sites where hydrophobic residues are favored. Proline is preferred at P3, and serine is preferred at P1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-26 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000036 | - |
N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan | - |
Homo sapiens | |
0.0000015 | - |
(3R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | - |
Homo sapiens | |
0.0000029 | - |
4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH | - |
Homo sapiens | |
0.00006 | - |
(3S)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0034 | - |
- |
Homo sapiens | 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH |