Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, chromosomal mapping to the short arm of chromosome 11 around 11p15, expression in Escherichia coli as His-tagged protein | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
matrix metalloproteinase inhibitor BB-94 | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains a zinc-binding site, coordination of zinc at the active site | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proteins + H2O | Homo sapiens | potentially implicated in tumor progression | peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NRE1 | enzyme shares minimal domain organisation and a threonine residue adjacent to the zinc-binding site with matrilysin | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | 2 N-glycosylation sites at residues 64 and 133 | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged protein from Escherichia coli | Homo sapiens |
Renatured (Comment) | Organism |
---|---|
refolding of recombinant protein from inclusion bodies expressed in Escherichia coli | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | lung carcinoma, gene expression | Homo sapiens | - |
endometrial adenocarcinoma cell | gene expression | Homo sapiens | - |
HL-60 cell | promyelocytic leukemia, gene expression | Homo sapiens | - |
lung adenocarcinoma cell | gene expression | Homo sapiens | - |
additional information | very restricted expression pattern | Homo sapiens | - |
placenta | gene expression | Homo sapiens | - |
prostate adenocarcinoma cell | gene expression | Homo sapiens | - |
SW-480 cell | colorectal adenocarcinoma, gene expression | Homo sapiens | - |
uterus | gene expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O | synthetic fluorogenic substrate | Homo sapiens | ? | - |
? | |
(7-methoxycoumarin-4-yl)acetyl-Pro-Cha-Gly-norvaline-His-Ala-Dpa-NH2 + H2O | synthetic fluorogenic substrate | Homo sapiens | ? | - |
? | |
Fibrinogen + H2O | complete degradation | Homo sapiens | ? | - |
? | |
Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
progelatinase B + H2O | substrate becomes activated, both enzymes can act as coordinately as part of a proteolytic cascade | Homo sapiens | gelatinase B | - |
? | |
proteins + H2O | wide substrate specificity | Homo sapiens | peptides | - |
? | |
proteins + H2O | potentially implicated in tumor progression | Homo sapiens | peptides | - |
? | |
Type IV collagen + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | minimal domain organization | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
endometase | - |
Homo sapiens |
M10.029 | Merops-ID | Homo sapiens |
matrix metalloproteinase-26 | - |
Homo sapiens |
MMP-26 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |