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Literature summary for 3.4.24.B7 extracted from

  • Uria, J.A.; Lopez-Otin, C.
    Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity (2000), Cancer Res., 60, 4745-4751.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, chromosomal mapping to the short arm of chromosome 11 around 11p15, expression in Escherichia coli as His-tagged protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
matrix metalloproteinase inhibitor BB-94
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains a zinc-binding site, coordination of zinc at the active site Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proteins + H2O Homo sapiens potentially implicated in tumor progression peptides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRE1 enzyme shares minimal domain organisation and a threonine residue adjacent to the zinc-binding site with matrilysin
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 2 N-glycosylation sites at residues 64 and 133 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged protein from Escherichia coli Homo sapiens

Renatured (Commentary)

Renatured (Comment) Organism
refolding of recombinant protein from inclusion bodies expressed in Escherichia coli Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell lung carcinoma, gene expression Homo sapiens
-
endometrial adenocarcinoma cell gene expression Homo sapiens
-
HL-60 cell promyelocytic leukemia, gene expression Homo sapiens
-
lung adenocarcinoma cell gene expression Homo sapiens
-
additional information very restricted expression pattern Homo sapiens
-
placenta gene expression Homo sapiens
-
prostate adenocarcinoma cell gene expression Homo sapiens
-
SW-480 cell colorectal adenocarcinoma, gene expression Homo sapiens
-
uterus gene expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O synthetic fluorogenic substrate Homo sapiens ?
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Cha-Gly-norvaline-His-Ala-Dpa-NH2 + H2O synthetic fluorogenic substrate Homo sapiens ?
-
?
Fibrinogen + H2O complete degradation Homo sapiens ?
-
?
Fibronectin + H2O
-
Homo sapiens ?
-
?
Gelatin + H2O
-
Homo sapiens ?
-
?
progelatinase B + H2O substrate becomes activated, both enzymes can act as coordinately as part of a proteolytic cascade Homo sapiens gelatinase B
-
?
proteins + H2O wide substrate specificity Homo sapiens peptides
-
?
proteins + H2O potentially implicated in tumor progression Homo sapiens peptides
-
?
Type IV collagen + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More minimal domain organization Homo sapiens

Synonyms

Synonyms Comment Organism
endometase
-
Homo sapiens
M10.029 Merops-ID Homo sapiens
matrix metalloproteinase-26
-
Homo sapiens
MMP-26
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens