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Literature summary for 3.4.24.B7 extracted from
- Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin (2001), Biochem. J., 356, 705-718.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination and analysis, chromosome mapping to 11p15.3, expression of the enzymes catalytic domain in Escherichia coli BL21 (DE3) | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hydroxamate inhibitors | - |
Homo sapiens | |
| matrix metalloproteinase inhibitor GM6001 | - |
Homo sapiens | |
| matrix metalloproteinase inhibitor TIMP-1 | - |
Homo sapiens | |
| matrix metalloproteinase inhibitor TIMP-2 | - |
Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proteins + H2O | Homo sapiens | enzyme plays an important specific role in tumor progression and angiogenesis | peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NRE1 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant catalytic domain from inclusion bodies expressed in Escherichia coli | Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| proteolytic degradation of proteins | consensus cleavage sequence is Pro-Glu-Xaa/Leu-Xaa-Thr-Xaa | Homo sapiens |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| refolding of recombinant catalytic domain from inclusion bodies expressed in Escherichia coli | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | fetal, gene expression | Homo sapiens | - |
| breast carcinoma cell | gene expression | Homo sapiens | - |
| colon | decending and transverse, gene expression | Homo sapiens | - |
| kidney | adult and fetal, gene expression | Homo sapiens | - |
| leukocyte | of peripheral blood, gene expression | Homo sapiens | - |
| lung cancer cell | gene expression | Homo sapiens | - |
| prostate | gene expression | Homo sapiens | - |
| prostate cancer cell | gene expression | Homo sapiens | - |
| skeletal muscle | fetal, gene expression | Homo sapiens | - |
| small intestine | gene expression | Homo sapiens | - |
| spleen | gene expression | Homo sapiens | - |
| testis | gene expression | Homo sapiens | - |
| thymus | fetal, gene expression | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (7-methoxycoumarin-4-yl)acetyl-PKPLAL-Dpa-AR-NH2 + H2O | synthetic fluorogenic peptide, catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
| (7-methoxycoumarin-4-yl)acetyl-PLGL-Dpa-AR-NH2 + H2O | synthetic fluorogenic peptide, derived from the catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
| (7-methoxycoumarin-4-yl)acetyl-RPKPVA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O | synthetic fluorogenic peptide, catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
| (7-methoxycoumarin-4-yl)acetyl-RPKPYA-norvaline-WMK-(2,4-dinitrophenyl)-NH2 + H2O | synthetic fluorogenic peptide, catalytic domain of the enzyme | Homo sapiens | ? | - |
? | |
| denatured collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibrinogen + H2O | complete degradation, cleavage sequenced of the peptide chains, overview | Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | cleavage sequence is PVA44-V45SQS | Homo sapiens | ? | - |
? | |
| proteins + H2O | wide substrate specificity | Homo sapiens | peptides | - |
? | |
| proteins + H2O | enzyme plays an important specific role in tumor progression and angiogenesis | Homo sapiens | peptides | - |
? | |
| Vitronectin + H2O | complete degradation, cleavage sequence is PPEG134-I135DSR | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M10.029 | Merops-ID | Homo sapiens |
| matrix metalloproteinase-26 | - |
Homo sapiens |
| MMP-26 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at, except for the assay with collagen as substrate at 25°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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