Literature summary for 3.4.24.B6 extracted from

Lu, Y.; Papagerakis, P.; Yamakoshi, Y.; Hu, J.C.; Bartlett, J.D.; Simmer, J.P.
Functions of KLK4 and MMP-20 in dental enamel formation (2008), Biol. Chem., 389, 695-700.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
enamel protein + H2O	Homo sapiens	MMP-20 is secreted along with enamel proteins by secretory stage ameloblasts into the enamel matrix of developing teeth. Enamel protein cleavage products accumulate in the space between the crystal ribbons, helping to support them. MMP-20 steadily cleaves accumulated enamel proteins, so their concentration decreases with depth. The principle functions of MMP-20 in dental enamel formation is to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60882	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
proteolytic cleavage of ameloblastin	MMP-20 is secreted along with enamel proteins by secretory stage ameloblasts into the enamel matrix of developing teeth. Enamel protein cleavage products accumulate in the space between the crystal ribbons, helping to support them. MMP-20 steadily cleaves accumulated enamel proteins, so their concentration decreases with depth. The principle functions of MMP-20 in dental enamel formation is to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins	Homo sapiens	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
ameloblast	MMP-20 is secreted along with enamel proteins by secretory stage ameloblasts into the enamel matrix of developing teeth	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
enamel protein + H2O	MMP-20 is secreted along with enamel proteins by secretory stage ameloblasts into the enamel matrix of developing teeth. Enamel protein cleavage products accumulate in the space between the crystal ribbons, helping to support them. MMP-20 steadily cleaves accumulated enamel proteins, so their concentration decreases with depth. The principle functions of MMP-20 in dental enamel formation is to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
enamelysin	-	Homo sapiens
MMP-20	-	Homo sapiens

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Release 2023.1 (January 2023)