BRENDA - Enzyme Database
show all sequences of 3.4.24.B6

Reduced amelogenin-MMP20 interactions in Amelogenesis imperfecta

Tanimoto, K.; Le, T.; Zhu, L.; Witkowska, H.E.; Robinson, S.; Hall, S.; Hwang, P.; DenBesten, P.; Li, W.; J. Dent. Res. 87, 451-455 (2008)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in Escherichia coli
Homo sapiens
Engineering
Protein Variants
Commentary
Organism
E227A
inactive; inactive mutant enzyme
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
SYGYEPMGGWLHHQ
competive against Mca-KPLGL-Dpa-AR-NH2
Homo sapiens
SYGYETMGGWLHHQ
competive against Mca-KPLGL-Dpa-AR-NH2
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
55000
-
SDS-PAGE; x * 55000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
amelogenin + H2O
Homo sapiens
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Homo sapiens
O60882
-
-
Purification (Commentary)
Purification (Commentary)
Organism
; recombinant wild-type and inactive mutant E227A
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
amelogenin + H2O
cleaves amelogenin between Trp45 and Leu46
688001
Homo sapiens
23 kDa amelogenin + 5 kDa tyrosine-rich amelogenin peptide
-
-
-
?
amelogenin + H2O
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis
688001
Homo sapiens
?
-
-
-
?
amelogenin + H2O
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis imperfecta. P41T mutation reduces the interactions between amelogenin and MMP20, leading to decreased degradation of amelogenin by MMP20, and resulting in amelogenesis imperfecta
688001
Homo sapiens
?
-
-
-
?
Mca-KPLGL-Dpa-AR-NH2 + H2O
-
688001
Homo sapiens
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 55000, SDS-PAGE
Homo sapiens
Synonyms
Synonyms
Commentary
Organism
matrix metalloproteinase 20
-
Homo sapiens
MMP20
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli
Homo sapiens
Engineering (protein specific)
Protein Variants
Commentary
Organism
E227A
inactive
Homo sapiens
E227A
inactive mutant enzyme
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
SYGYEPMGGWLHHQ
competive against Mca-KPLGL-Dpa-AR-NH2
Homo sapiens
SYGYETMGGWLHHQ
competive against Mca-KPLGL-Dpa-AR-NH2
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
55000
-
SDS-PAGE
Homo sapiens
55000
-
x * 55000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
amelogenin + H2O
Homo sapiens
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis
?
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
recombinant wild-type and inactive mutant E227A
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
amelogenin + H2O
cleaves amelogenin between Trp45 and Leu46
688001
Homo sapiens
23 kDa amelogenin + 5 kDa tyrosine-rich amelogenin peptide
-
-
-
?
amelogenin + H2O
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis
688001
Homo sapiens
?
-
-
-
?
amelogenin + H2O
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis imperfecta. P41T mutation reduces the interactions between amelogenin and MMP20, leading to decreased degradation of amelogenin by MMP20, and resulting in amelogenesis imperfecta
688001
Homo sapiens
?
-
-
-
?
Mca-KPLGL-Dpa-AR-NH2 + H2O
-
688001
Homo sapiens
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 55000, SDS-PAGE
Homo sapiens
Other publictions for EC 3.4.24.B6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
754270
Yamazaki
Proteolysis by MMP20 prevents ...
Mus musculus
J. Dent. Res.
98
468-475
2019
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1
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1
1
-
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-
753160
Gomes-Silva
Postradiation matrix metallop ...
Homo sapiens
Caries Res.
51
216-224
2017
-
1
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2
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2
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753705
Kim
Analyses of MMP20 missense mu ...
Homo sapiens
Front. Physiol.
8
229
2017
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3
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752909
Prajapati
Matrix metalloproteinase-20 m ...
Mus musculus
Biomaterials
75
260-270
2016
-
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3
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1
1
-
-
-
754269
Kwak
MMP20 Proteolysis of native a ...
Sus scrofa
J. Dent. Res.
95
1511-1517
2016
-
-
-
-
-
-
-
-
-
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3
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1
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2
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-
-
-
754322
Ogbureke
Matrix metalloproteinase 20 c ...
Homo sapiens, Macaca fascicularis
J. Histochem. Cytochem.
64
623-636
2016
-
-
-
-
-
-
-
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4
-
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9
-
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9
-
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-
755434
Shin
Murine matrix metalloproteina ...
Mus musculus
Sci. Rep.
6
29492
2016
-
-
-
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3
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2
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-
1
1
-
-
-
734404
Koli
Expression of matrix metallopr ...
Homo sapiens
J. Histochem. Cytochem.
63
524-533
2015
-
-
-
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2
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1
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1
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1
1
-
-
-
754268
Seymen
Novel MMP20 and KLK4 mutation ...
Homo sapiens
J. Dent. Res.
94
1063-1069
2015
-
-
-
-
1
-
-
-
-
-
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1
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-
735135
Shin
Matrix metalloproteinase-20 ov ...
Mus musculus
PLoS ONE
9
e86774
2014
-
-
-
-
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-
-
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-
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3
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3
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3
-
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-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
733390
Khan
The proteolytic processing of ...
Homo sapiens
Biochim. Biophys. Acta
1830
2600-2607
2013
-
-
1
-
-
-
-
5
-
-
-
-
-
2
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-
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-
1
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-
5
-
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1
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5
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1
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-
5
-
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-
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-
4
4
718711
Uskokovic
Hydrolysis of amelogenin by ma ...
Homo sapiens
Arch. Oral Biol.
56
1548-1559
2011
-
-
1
-
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-
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1
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1
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1
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2
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1
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1
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1
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-
1
1
-
-
-
719262
Bartlett
MMP20 cleaves E-cadherin and i ...
Mus musculus, Sus scrofa
Cells Tissues Organs
194
222-226
2011
-
-
-
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2
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3
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2
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1
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2
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2
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1
-
-
2
-
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-
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-
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-
-
3
3
-
-
-
720338
Yang
Amelogenin nanorods formation ...
Sus scrofa
J. Struct. Biol.
176
220-228
2011
-
-
1
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-
-
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-
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2
-
2
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1
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2
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2
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1
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2
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1
1
-
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-
712555
Lee
The odontogenic ameloblast-ass ...
Mus musculus
J. Cell. Biochem.
111
755-767
2010
-
-
1
-
-
-
-
-
1
1
-
1
-
1
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4
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3
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1
1
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1
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1
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4
-
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3
-
1
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1
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2
1
1
2
-
-
712587
Sun
Apatite reduces amelogenin pro ...
Sus scrofa
J. Dent. Res.
89
344-348
2010
-
-
1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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2
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1
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1
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1
1
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-
712589
Lee
MMP20 hemopexin domain mutatio ...
Homo sapiens
J. Dent. Res.
89
46-50
2010
-
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1
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3
-
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1
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1
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2
2
-
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712590
Chun
Cleavage site specificity of M ...
Sus scrofa
J. Dent. Res.
89
785-790
2010
-
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1
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1
1
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3
-
1
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1
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3
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5
-
3
1
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1
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1
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1
1
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3
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1
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3
-
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5
-
1
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1
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1
1
-
-
-
710860
Gao
TGF-beta1 and TGFBR1 are expre ...
Mus musculus
Anat. Rec. (Hoboken)
292
885-890
2009
-
-
-
-
-
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-
-
-
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-
1
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4
-
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4
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
712586
Nagano
Mmp-20 and Klk4 cleavage site ...
Sus scrofa
J. Dent. Res.
88
823-828
2009
-
-
-
-
-
-
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-
1
1
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1
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2
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1
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2
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4
-
2
1
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1
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1
1
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1
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1
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2
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4
-
1
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-
-
1
-
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1
1
-
-
-
713340
Wheeler
Sequential use of transcriptio ...
Homo sapiens
PLoS Genet.
5
e1000685
2009
-
-
1
-
1
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-
-
-
-
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2
-
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2
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1
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1
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Comparative properties of reco ...
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Reduced amelogenin-MMP20 inter ...
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Functions of KLK4 and MMP-20 i ...
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Arendt
Catalytic domain of MMP20 (ena ...
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Identification and characteriz ...
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Iwata
Processing of ameloblastin by ...
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Turk
MMP-20 is predominately a toot ...
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4
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Zhang
Fluoride down-regulates the ex ...
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2006
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Bartlett
A developmental comparison of ...
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Bourd-Boittin
Matrix metalloproteinase inhib ...
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Kim
MMP-20 mutation in autosomal r ...
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Bartlett
Decreased mineral content in M ...
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2004
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Bourd-Boittin
Immunolocalization of enamelys ...
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2004
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Terp
Structural differences of matr ...
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Stracke
Matrix metalloproteinases 19 a ...
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Ferreras
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Caterina
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Li
Activation of recombinant bovi ...
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Ryu
Characterization of recombinan ...
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692512
Caterina
Isolation, characterization, a ...
Mus musculus
Genomics
62
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Llano
Identification and structural ...
Homo sapiens
Biochemistry
36
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