BRENDA - Enzyme Database
show all sequences of 3.4.24.B6

Comparative properties of recombinant human and bovine matrix metalloproteinase-20

Zhu, L.; Tanimoto, K.; Robinsin, S.; Chen, J.; Witkowska, E.; Hall, S.; Le, T.; Denbesten, P.K.; Li, W.; Arch. Oral Biol. 53, 785-790 (2008)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in Escherichia coli BL21(DE3) cells; expression in Escherichia coli
Bos taurus
expressed in Escherichia coli BL21(DE3) cells; expression in Escherichia coli
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0143
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Bos taurus
0.0143
-
Mca-PLGL-Dpa-AR
37C
Bos taurus
0.0164
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Homo sapiens
0.0164
-
Mca-PLGL-Dpa-AR
37C
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Bos taurus
Zn2+
-
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
55000
-
SDS-PAGE; x * 55000, SDS-PAGE
Bos taurus
55000
-
SDS-PAGE; x * 55000, SDS-PAGE
Homo sapiens
Organism
Organism
UniProt
Commentary
Textmining
Bos taurus
-
-
-
Bos taurus
O18767
-
-
Homo sapiens
-
-
-
Homo sapiens
O60882
-
-
Purification (Commentary)
Purification (Commentary)
Organism
; nickel resin chromatography
Bos taurus
; nickel resin chromatography
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
tooth
fetal tooth tissue
Bos taurus
-
tooth
fetal tooth tissue
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
amelogenin + H2O
cleavage loci: FSY/EVL, GGW/LHH, MFP/MQP, MLP/DLT, DLT/LEA, LTL/EAW, AWP/STD
684767
Homo sapiens
?
-
-
-
?
amelogenin + H2O
cleavage loci: FSY/EVL, GGW/LHH, MFP/MQP, MLP/DLT, LTL/EAW, AWP/STD
684767
Bos taurus
?
-
-
-
?
amylogenin + H2O
-
684767
Homo sapiens
?
-
-
-
?
amylogenin + H2O
-
684767
Bos taurus
?
-
-
-
?
Mca-PLGL-Dpa-AR + H2O
-
684767
Homo sapiens
?
-
-
-
?
Mca-PLGL-Dpa-AR + H2O
-
684767
Bos taurus
?
-
-
-
?
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2 + H2O
-
684767
Homo sapiens
?
-
-
-
?
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2 + H2O
-
684767
Bos taurus
?
-
-
-
?
additional information
MMP-20 becomes functionally active when proteolytic cleavage removes the pro-domain to expose the zinc atom and free the active site for the enzyme to interact with its substrate
684767
Homo sapiens
?
-
-
-
-
additional information
MMP-20 becomes functionally active when proteolytic cleavage removes the pro-domain to expose the zinc atom and free the active site for the enzyme to interact with its substrate
684767
Bos taurus
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 55000, SDS-PAGE
Homo sapiens
?
x * 55000, SDS-PAGE
Bos taurus
Synonyms
Synonyms
Commentary
Organism
MMP-20
-
Bos taurus
MMP-20
-
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
8.1
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Homo sapiens
8.1
-
Mca-PLGL-Dpa-AR
37C
Homo sapiens
9
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Bos taurus
9
-
Mca-PLGL-Dpa-AR
37C
Bos taurus
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Bos taurus
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
expression in Escherichia coli
Homo sapiens
expression in Escherichia coli
Bos taurus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0143
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Bos taurus
0.0143
-
Mca-PLGL-Dpa-AR
37C
Bos taurus
0.0164
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Homo sapiens
0.0164
-
Mca-PLGL-Dpa-AR
37C
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
-
Bos taurus
Zn2+
-
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
55000
-
SDS-PAGE
Bos taurus
55000
-
x * 55000, SDS-PAGE
Bos taurus
55000
-
SDS-PAGE
Homo sapiens
55000
-
x * 55000, SDS-PAGE
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
-
Bos taurus
-
Homo sapiens
nickel resin chromatography
Bos taurus
nickel resin chromatography
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
tooth
fetal tooth tissue
Bos taurus
-
tooth
fetal tooth tissue
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
amelogenin + H2O
cleavage loci: FSY/EVL, GGW/LHH, MFP/MQP, MLP/DLT, DLT/LEA, LTL/EAW, AWP/STD
684767
Homo sapiens
?
-
-
-
?
amelogenin + H2O
cleavage loci: FSY/EVL, GGW/LHH, MFP/MQP, MLP/DLT, LTL/EAW, AWP/STD
684767
Bos taurus
?
-
-
-
?
amylogenin + H2O
-
684767
Homo sapiens
?
-
-
-
?
amylogenin + H2O
-
684767
Bos taurus
?
-
-
-
?
Mca-PLGL-Dpa-AR + H2O
-
684767
Homo sapiens
?
-
-
-
?
Mca-PLGL-Dpa-AR + H2O
-
684767
Bos taurus
?
-
-
-
?
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2 + H2O
-
684767
Homo sapiens
?
-
-
-
?
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2 + H2O
-
684767
Bos taurus
?
-
-
-
?
additional information
MMP-20 becomes functionally active when proteolytic cleavage removes the pro-domain to expose the zinc atom and free the active site for the enzyme to interact with its substrate
684767
Homo sapiens
?
-
-
-
-
additional information
MMP-20 becomes functionally active when proteolytic cleavage removes the pro-domain to expose the zinc atom and free the active site for the enzyme to interact with its substrate
684767
Bos taurus
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 55000, SDS-PAGE
Homo sapiens
?
x * 55000, SDS-PAGE
Bos taurus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
8.1
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Homo sapiens
8.1
-
Mca-PLGL-Dpa-AR
37C
Homo sapiens
9
-
Mca-PLGL-[3-DNP-2,3-DAP]-AR-NH2
at 37C
Bos taurus
9
-
Mca-PLGL-Dpa-AR
37C
Bos taurus
Other publictions for EC 3.4.24.B6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
754270
Yamazaki
Proteolysis by MMP20 prevents ...
Mus musculus
J. Dent. Res.
98
468-475
2019
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-
-
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-
-
-
-
-
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3
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1
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1
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1
1
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-
753160
Gomes-Silva
Postradiation matrix metallop ...
Homo sapiens
Caries Res.
51
216-224
2017
-
1
-
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2
-
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2
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1
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2
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753705
Kim
Analyses of MMP20 missense mu ...
Homo sapiens
Front. Physiol.
8
229
2017
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3
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2
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-
752909
Prajapati
Matrix metalloproteinase-20 m ...
Mus musculus
Biomaterials
75
260-270
2016
-
-
-
-
-
-
-
-
-
-
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-
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3
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-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
754269
Kwak
MMP20 Proteolysis of native a ...
Sus scrofa
J. Dent. Res.
95
1511-1517
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
2
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1
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
754322
Ogbureke
Matrix metalloproteinase 20 c ...
Homo sapiens, Macaca fascicularis
J. Histochem. Cytochem.
64
623-636
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
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-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
755434
Shin
Murine matrix metalloproteina ...
Mus musculus
Sci. Rep.
6
29492
2016
-
-
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3
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2
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2
-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
734404
Koli
Expression of matrix metallopr ...
Homo sapiens
J. Histochem. Cytochem.
63
524-533
2015
-
-
-
-
-
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2
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1
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1
-
-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
754268
Seymen
Novel MMP20 and KLK4 mutation ...
Homo sapiens
J. Dent. Res.
94
1063-1069
2015
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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2
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1
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735135
Shin
Matrix metalloproteinase-20 ov ...
Mus musculus
PLoS ONE
9
e86774
2014
-
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3
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3
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3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
733390
Khan
The proteolytic processing of ...
Homo sapiens
Biochim. Biophys. Acta
1830
2600-2607
2013
-
-
1
-
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5
-
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2
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1
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5
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1
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5
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1
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-
5
-
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-
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-
4
4
718711
Uskokovic
Hydrolysis of amelogenin by ma ...
Homo sapiens
Arch. Oral Biol.
56
1548-1559
2011
-
-
1
-
-
-
-
-
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1
-
1
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1
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2
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1
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1
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1
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-
-
-
-
-
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-
1
1
-
-
-
719262
Bartlett
MMP20 cleaves E-cadherin and i ...
Mus musculus, Sus scrofa
Cells Tissues Organs
194
222-226
2011
-
-
-
-
-
-
-
-
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2
-
3
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2
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1
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2
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2
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2
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2
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1
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2
-
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-
-
-
-
-
-
-
3
3
-
-
-
720338
Yang
Amelogenin nanorods formation ...
Sus scrofa
J. Struct. Biol.
176
220-228
2011
-
-
1
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-
-
-
-
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2
-
2
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1
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2
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2
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1
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2
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1
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2
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-
-
-
-
-
-
-
-
-
1
1
-
-
-
712555
Lee
The odontogenic ameloblast-ass ...
Mus musculus
J. Cell. Biochem.
111
755-767
2010
-
-
1
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
-
4
-
-
3
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
4
-
-
3
-
1
-
-
-
1
-
-
-
2
1
1
2
-
-
712587
Sun
Apatite reduces amelogenin pro ...
Sus scrofa
J. Dent. Res.
89
344-348
2010
-
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
2
1
-
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1
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-
1
-
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-
-
1
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1
-
-
1
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-
-
1
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
712589
Lee
MMP20 hemopexin domain mutatio ...
Homo sapiens
J. Dent. Res.
89
46-50
2010
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Caterina
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