BRENDA - Enzyme Database show
show all sequences of 3.4.24.B6

MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta

Kim, J.; Simmer, J.P.; Hart, T.C.; Hart, P.S.; Ramaswami, M.D.; Bartlett, J.D.; Hu, J.C.; J. Med. Genet. 42, 271-275 (2005)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
first report of a homozygous mutation in the MMP-20 gene, the mutation destroys the splice acceptor sequence at the 3' end of intron 6 encoding the hemopexin domain, the enamel of the subjects' teeth is pigmented, its surface mottled and rough and the enamel layer more opaque than the underlying dentine
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
tooth
-
Homo sapiens
-
Application (protein specific)
Application
Commentary
Organism
medicine
first report of a homozygous mutation in the MMP-20 gene, the mutation destroys the splice acceptor sequence at the 3' end of intron 6 encoding the hemopexin domain, the enamel of the subjects' teeth is pigmented, its surface mottled and rough and the enamel layer more opaque than the underlying dentine
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
tooth
-
Homo sapiens
-
Other publictions for EC 3.4.24.B6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734404
Koli
Expression of matrix metallopr ...
Homo sapiens
J. Histochem. Cytochem.
63
524-533
2015
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1
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735135
Shin
Matrix metalloproteinase-20 ov ...
Mus musculus
PLoS ONE
9
e86774
2014
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1
1
1
1
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733390
Khan
The proteolytic processing of ...
Homo sapiens
Biochim. Biophys. Acta
1830
2600-2607
2013
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5
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1
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5
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4
4
718711
Uskokovic
Hydrolysis of amelogenin by ma ...
Homo sapiens
Arch. Oral Biol.
56
1548-1559
2011
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1
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1
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1
1
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719262
Bartlett
MMP20 cleaves E-cadherin and i ...
Mus musculus, Sus scrofa
Cells Tissues Organs
194
222-226
2011
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1
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2
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3
3
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720338
Yang
Amelogenin nanorods formation ...
Sus scrofa
J. Struct. Biol.
176
220-228
2011
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1
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712555
Lee
The odontogenic ameloblast-ass ...
Mus musculus
J. Cell. Biochem.
111
755-767
2010
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1
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1
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1
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1
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1
1
2
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712587
Sun
Apatite reduces amelogenin pro ...
Sus scrofa
J. Dent. Res.
89
344-348
2010
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1
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1
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1
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1
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712589
Lee
MMP20 hemopexin domain mutatio ...
Homo sapiens
J. Dent. Res.
89
46-50
2010
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1
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3
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1
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2
2
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712590
Chun
Cleavage site specificity of M ...
Sus scrofa
J. Dent. Res.
89
785-790
2010
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1
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710860
Gao
TGF-beta1 and TGFBR1 are expre ...
Mus musculus
Anat. Rec. (Hoboken)
292
885-890
2009
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1
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712586
Nagano
Mmp-20 and Klk4 cleavage site ...
Sus scrofa
J. Dent. Res.
88
823-828
2009
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1
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713340
Wheeler
Sequential use of transcriptio ...
Homo sapiens
PLoS Genet.
5
e1000685
2009
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1
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684767
Zhu
Comparative properties of reco ...
Bos taurus, Homo sapiens
Arch. Oral Biol.
53
785-790
2008
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2
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4
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2
2
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8
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2
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10
2
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4
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4
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4
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2
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10
2
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4
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688001
Tanimoto
Reduced amelogenin-MMP20 inter ...
Homo sapiens
J. Dent. Res.
87
451-455
2008
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1
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1
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1
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1
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691154
Lu
Functions of KLK4 and MMP-20 i ...
Homo sapiens
Biol. Chem.
389
695-700
2008
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686743
Arendt
Catalytic domain of MMP20 (ena ...
Homo sapiens
FEBS Lett.
581
4723-4726
2007
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1
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686936
Shintani
Identification and characteriz ...
Caiman crocodilus, Xenopus laevis
Gene
392
89-97
2007
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7
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688000
Iwata
Processing of ameloblastin by ...
Sus scrofa
J. Dent. Res.
86
153-157
2007
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667722
Turk
MMP-20 is predominately a toot ...
Homo sapiens, Mus musculus
Biochemistry
45
3863-3874
2006
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1
2
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1
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669508
Yamakoshi
Dentin sialophosphoprotein is ...
Sus scrofa
J. Biol. Chem.
281
38235-38243
2006
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684397
Wang
On-column activation of bovine ...
Bos taurus
Anal. Biochem.
356
291-293
2006
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686541
Zhang
Fluoride down-regulates the ex ...
Homo sapiens
Eur. J. Oral Sci.
114
105-110
2006
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686542
Bartlett
A developmental comparison of ...
Mus musculus
Eur. J. Oral Sci.
114
18-23
2006
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668499
Bourd-Boittin
Matrix metalloproteinase inhib ...
Mus musculus
Exp. Cell Res.
304
493-505
2005
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1
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1
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2
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2
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669815
Kim
MMP-20 mutation in autosomal r ...
Homo sapiens
J. Med. Genet.
42
271-275
2005
-
1
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669647
Bartlett
Decreased mineral content in M ...
Mus musculus, Mus musculus C57BL6
J. Dent. Res.
83
909-913
2004
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1
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1
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11
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