Literature summary for 3.4.24.B6 extracted from

Turk, B.E.; Lee, D.H.; Yamakoshi, Y.; Klingenhoff, A.; Reichenberger, E.; Wright, J.T.; Simmer, J.P.; Komisarof, J.A.; Cantley, L.C.; Bartlett, J.D.
MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen (2006), Biochemistry, 45, 3863-3874.

Search for more literature for 3.4.24.B6

Application

Application	Comment	Organism
additional information	MMP-20 expression is primarly confined to tooth tissue	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus
expression in Escherichia coli as an N-terminal His6 fusion	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E235A	enzymatically inactive MMP-20	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	Q3LRH7	-	-

Purification (Commentary)

Purification (Comment)	Organism
purified on Ni column	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
large intestine	minute quantities, 5000fold lower than in 4-day-old first molar tooth buds	Mus musculus	-
additional information	not detected in bladder, eye, spleen, stomach and thymus	Mus musculus	-
tooth bud	only in jaw containing the developing tooth buds appreciable levels of the enzyme	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	type III collagen can not be cleaved	Homo sapiens	?	-	?
type V collagen + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
enamelysin	-	Homo sapiens
enamelysin	-	Mus musculus
MMP-20	-	Homo sapiens
MMP-20	-	Mus musculus

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Release 2023.1 (January 2023)