Literature summary for 3.4.24.B6 extracted from

Terp, G.E.; Cruciani, G.; Christensen, I.T.; Jorgensen, F.S.
Structural differences of matrix metalloproteinases with potential implications for inhibitor selectivity examined by the GRID/CPCA approach (2002), J. Med. Chem., 45, 2675-2684.

Search for more literature for 3.4.24.B6

Application

Application	Comment	Organism
pharmacology	enzyme is a potential target for selective inhibition and inhibitor design	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibitor design, determination of the features of the individual binding pockets of the enzyme	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	dependent on	Homo sapiens
Zn2+	dependent on	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
proteins + H2O	Homo sapiens	-	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60882	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
proteolytic degradation of ameloblastin	mechanism and active site structure analysis, binding pockets and substrate specificity	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
proteins + H2O	-	Homo sapiens	peptides	-	?

Subunits

Subunits	Comment	Organism
More	structure analysis and modeling	Homo sapiens

Synonyms

Synonyms	Comment	Organism
enamel metalloproteinase	-	Homo sapiens
enamelysin	-	Homo sapiens
M10.019	Merops-ID	Homo sapiens
MMP-20	-	Homo sapiens

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Release 2023.1 (January 2023)