Literature summary for 3.4.24.B5 extracted from

Shofuda, K.I.; Moriyama, K.; Nishihashi, A.; Higashi, S.; Mizushima, H.; Yasumitsu, H.; Miki, K.; Sato, H.; Seiki, M.; Miyazaki, K.
Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells (1998), J. Biochem., 124, 462-470.

Search for more literature for 3.4.24.B5

Activating Compound

Activating Compound	Comment	Organism	Structure
12-O-tetradecanoyl phorbol 13-acetate	activates enzyme expression	Homo sapiens
concanavalin A	regulatory role, activates enzyme expression and activity, effect is inhibited by matrix metalloproteinase inhibitor TIMP-2	Homo sapiens
tissue matrix metalloprotease inhibitor TIMP-2	regulatory role, expression and protein levels in cancer cell lines are not corresponding, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
matrix metalloproteinase inhibitor TIMP-2	regulatory function, forms complex with the enzyme on the surface of cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	on the cell surface	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protein + H2O	Homo sapiens	-	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	membrane-type-1, -type-2 and -type-3 matrix metalloproteases	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
G-361 cell	cancer cell line, low expression of MT2 MMP	Homo sapiens	-
HeLa-S3 cell	cancer cell line, expressing the proform gelatinase A, concanavalin A induces MT2 MMP expression	Homo sapiens	-
HSC-3 cell	squamous carcinoma cell line, expresssion of MT2 MMP not MT1 MMP and MT3 MMP	Homo sapiens	-
HSC-4 cell	squamous carcinoma cell line, expresssion of MT2 MMP not MT1 MMP and MT3 MMP	Homo sapiens	-
HT-1080 cell	expresssion of MT2 MMP not MT1 MMP and MT3 MMP, cancer cell line, expressing the proform gelatinase A, concanavalin A supresses the expression of MT1 MMP	Homo sapiens	-
T-24 cell	cancer cell line, low expression of MT2 MMP	Homo sapiens	-
T-98G cell	cancer cell line, low expression of MT2 MMP	Homo sapiens	-
U-87MG cell	cancer cell line, low expression of MT2 MMP and expression of MT3 MMP	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
progelatinase A + H2O	substrate is activated by cleavage	Homo sapiens	gelatinase A + ?	-	?
protein + H2O	-	Homo sapiens	peptides	-	?

Synonyms

Synonyms	Comment	Organism
M10.015	Merops-ID	Homo sapiens
membrane-type-1 matrix metalloproteinase	-	Homo sapiens
membrane-type-2 matrix metalloproteinase	-	Homo sapiens
membrane-type-3 matrix metalloproteinase	-	Homo sapiens
MT1 MMP	-	Homo sapiens
MT2 MMP	-	Homo sapiens

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Release 2023.1 (January 2023)