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Literature summary for 3.4.24.B4 extracted from

  • De Savi, C.; Morley, A.D.; Ting, A.; Nash, I.; Karabelas, K.; Wood, C.M.; James, M.; Norris, S.J.; Karoutchi, G.; Rankine, N.; Hamlin, G.; Macfaul, P.A.; Ryan, D.; Baker, S.V.; Hargreaves, D.; Gerhardt, S.
    Selective non zinc binding inhibitors of MMP13 (2011), Bioorg. Med. Chem. Lett., 21, 4215-4219.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Activating Compound

Activating Compound Comment Organism Structure
p-aminophenylmercuric acetate purified proMMP-13 is activated using 1 mM amino phenyl mercuric acid for 20 h at 35°C Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-(2-cyanophenoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(2-phenylethoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(3-methoxy-4-nitrophenoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(4-methylphenoxy)-N-(pyridin-3-ylmethyl)benzamide
-
 Homo sapiens
4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(4-methylphenoxy)-N-[2-(pyridin-4-yl)ethyl]benzamide
-
 Homo sapiens
4-(4-nitrophenoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(4-[[(3R)-3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl]ethynyl]phenoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(4-[[(3R)-3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl]ethynyl]phenoxy)-N-(pyrimidin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(4-[[(3S)-3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl]ethynyl]phenoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(4-[[(3S)-3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl]ethynyl]phenoxy)-N-(pyrimidin-4-ylmethyl)benzamide
-
 Homo sapiens
4-(benzyloxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-methoxy-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-phenoxy-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[4-(methylcarbamoyl)phenoxy]-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[4-[(3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl)ethynyl]phenoxy]-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[4-[(3-methoxy-1-azabicyclo[2.2.2]oct-3-yl)ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[4-[(E)-2-(1-azabicyclo[2.2.2]oct-2-en-3-yl)ethenyl]phenoxy]-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[4-[(E)-2-(1-azabicyclo[2.2.2]oct-2-en-3-yl)ethenyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[4-[(E)-2-(3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl)ethenyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[4-[2-(3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl)ethyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide
-
 Homo sapiens
4-[[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl]benzoic acid
-
 Homo sapiens
N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide
-
 Homo sapiens
N-(2-hydroxyethyl)-4-(4-methylphenoxy)benzamide
-
 Homo sapiens
N-(3-methoxybenzyl)-4-(4-methylphenoxy)benzamide
-
 Homo sapiens
N-(cyclohexylmethyl)-4-(4-methylphenoxy)benzamide
-
 Homo sapiens
N-(pyridin-4-ylmethyl)biphenyl-4-carboxamide
-
 Homo sapiens
N-benzyl-4-(4-methylphenoxy)benzamide
-
 Homo sapiens
N-methyl-4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide
-
 Homo sapiens
N-methyl-4-(4-methylphenoxy)benzamide
-
 Homo sapiens
N-[3-(dimethylamino)propyl]-4-(4-methylphenoxy)benzamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen type II + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen type II + H2O
-
 Homo sapiens ?
-
 ?
Mca-Pro-(cyclohexyl)-Ala-Gly-Nva-His-Ala-Dap-(Dnp)-NH2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
collagenase 3
-
 Homo sapiens
MMP13
-
 Homo sapiens