Protein Variants | Comment | Organism |
---|---|---|
additional information | MMP13 knockout mice are viable, healthy, and grossly normal. The absence of MMP13, however, delays the endochondral ossification process of skeletal development, knockout phenotype, overview. The mutant mice show hypertrophic chondrocytes within the articular cartilage of trabecular bone that is due to impaired remodeling of the extracellular matrix, and they show reduced apoptosis of the hypertrophic chondrocytes. Tibial cartilage erosion does not progress with time in MMP13 knockout mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R)-4-[[4-(2-chloro-4-fluorophenoxy)phenyl]sulfonyl]-N,2-dihydroxy-2-methylmorpholine-3-carboxamide | - |
Homo sapiens | |
(2S,3R)-1-acetyl-N-hydroxy-2-methyl-4-[[4-(2-methylbenzyl)phenyl]sulfonyl]piperidine-3-carboxamide | - |
Homo sapiens | |
(4R)-1-[4-(4-fluorophenoxy)benzyl]-N-hydroxy-2-oxoimidazolidine-4-carboxamide | - |
Homo sapiens | |
(4S)-4-[4-(4-fluorophenoxy)phenyl]-N-hydroxy-5-oxo-D-prolinamide | - |
Homo sapiens | |
1,5-anhydro-2,3-dideoxy-3-[[4-(2,4-dichlorophenoxy)phenyl]sulfonyl]-4-C-(hydroxycarbamoyl)-D-threo-pentitol | - |
Homo sapiens | |
1-(4-amino-2-methylquinolin-6-yl)-3-(4-methoxyphenyl)urea | - |
Homo sapiens | |
1-(4-phenoxyphenyl)-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone | - |
Homo sapiens | |
1-(6-[4-[4-(4-fluorophenyl)-1,3-oxazol-2-yl]phenoxy]pyridin-3-yl)-1,7,9-triazaspiro[4.5]decane-6,8,10-trione | - |
Homo sapiens | |
2-(ethyl[[4-(prop-1-yn-1-yloxy)phenyl]sulfonyl]amino)-5-phenylpentane(thioperox)ic O-acid | - |
Homo sapiens | |
2-fluoro-N-hydroxy-6-([4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]sulfonyl)benzamide | - |
Homo sapiens | |
2-[(4-chlorobenzyl)sulfanyl]-6-methylpyrimidin-4-ol | competitive | Homo sapiens | |
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3,5-dimethylbenzamide | WAY- 152177 | Homo sapiens | |
2-[[(4'-chlorobiphenyl-4-yl)oxy]methyl]-N-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanamide | - |
Homo sapiens | |
2-[[(4'-cyanobiphenyl-4-yl)oxy]methyl]-N-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanamide | - |
Homo sapiens | |
2-[[(4'-[[(5-bromo-4-methoxy-3-methyl-1-benzofuran-2-yl)carbonyl]amino]biphenyl-4-yl)sulfonyl]methyl]-3-methylbutanoic acid | - |
Homo sapiens | |
2-[[[4-(4-chlorophenoxy)phenyl]sulfonyl](methyl)amino]-N-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzamide | - |
Homo sapiens | |
3-[(4-methoxyphenyl)sulfonyl]propane-1-thiol | - |
Homo sapiens | |
3-[(4-phenoxyphenyl)sulfonyl]cyclohexanethiol | - |
Homo sapiens | |
3-[[4-(phenylsulfanyl)phenyl]sulfonyl]cyclohexanethiol | - |
Homo sapiens | |
4'-aminobiphenyl-4-sulfonamide | competitive | Homo sapiens | |
4-(3-[3-[3-(3,4-difluorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]prop-2-yn-1-yl]phenyl)butanoic acid | - |
Homo sapiens | |
4-([6-[(4-methoxybenzyl)carbamoyl]-4-oxopyrido[3,4-d]pyrimidin-3(4H)-yl]methyl)benzoic acid | a less potent MMP13 inhibitor | Homo sapiens | |
4-([[4-(4-fluorophenoxy)phenyl]sulfonyl]amino)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | - |
Homo sapiens | |
4-methoxy-N,N'-bis(pyridin-3-ylmethyl)benzene-1,3-dicarboxamide | competitive | Homo sapiens | |
4-[2-[4-(4-[[5-(2-ethoxyethyl)-2,4,6-trioxohexahydropyrimidin-5-yl]oxy]phenoxy)phenyl]-1,3-oxazol-4-yl]benzonitrile | - |
Homo sapiens | |
4-[[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl]benzoic acid | noncompetitive, extremely selective for inhibition of MMP13 over all other MMPs | Homo sapiens | |
4-[[4-oxo-6-(3-phenylprop-1-yn-1-yl)quinazolin-3(4H)-yl]methyl]benzoic acid | - |
Homo sapiens | |
4-[[6-(2-[3-[3-(hydroxyamino)-3-oxopropoxy]phenyl]-1,3-oxazol-5-yl)-4-oxoquinazolin-3(4H)-yl]methyl]benzoic acid | - |
Homo sapiens | |
5-(2-ethoxyethyl)-5-[4-[4-(1,3,4-oxadiazol-2-yl)phenoxy]phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione | - |
Homo sapiens | |
5-(3,4-difluorobenzyl)-7-methyl-4,6-dioxo-N-[[2-(3-sulfanylpropoxy)pyridin-4-yl]methyl]-3a,4,5,6-tetrahydrothieno[3,2-c]pyridine-2-carboxamide | - |
Homo sapiens | |
5-(4-chlorophenoxy)-5-methylpyrimidine-2,4,6(1H,3H,5H)-trione | - |
Homo sapiens | |
5-hexyl-5-(4-phenoxyphenoxy)pyrimidine-2,4,6(1H,3H,5H)-trione | - |
Homo sapiens | |
5-methyl-5-(4-phenoxyphenoxy)pyrimidine-2,4,6(1H,3H,5H)-trione | - |
Homo sapiens | |
5-[4-(1H-imidazol-1-yl)phenyl]-4-methyl-1,2-dihydro-3H-pyrazol-3-one | - |
Homo sapiens | |
benzyl 6-benzyl-5,7-dioxo-6,7-dihydro-5H-[1,3]thiazolo[3,2-c]pyrimidine-2-carboxylate | competitive, does not ligate the catalytic zinc, zinc binding is unnecessary to achieve nanomolar affinity, extremely selective for inhibition of MMP13 over all other MMPs | Homo sapiens | |
marimastat | a nonselective inhibitor | Rattus norvegicus | |
methyl 3-[4-(1H-imidazol-1-yl)phenyl]propanoate | - |
Homo sapiens | |
additional information | structure-function relationships of different inhibitor types, overview. No inhibition by 27, i.e. CGS27023A | Homo sapiens | |
N,N'-bis(3-methylbenzyl)pyrimidine-4,6-dicarboxamide | extremely selective for inhibition of MMP13 over all other MMPs | Homo sapiens | |
N,N'-bis(3-methylbenzyl)pyrimidine-4,6-dicarboxamide | a MMP13-specific inhibitor | Rattus norvegicus | |
N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide | - |
Homo sapiens | |
N-([4'-[(1-benzofuran-2-ylcarbonyl)amino]biphenyl-4-yl]sulfonyl)valine | - |
Homo sapiens | |
N-([4'-[([4-[(2-carboxypropan-2-yl)oxy]-1-benzofuran-2-yl]carbonyl)amino]biphenyl-4-yl]sulfonyl)-L-valine | - |
Homo sapiens | |
N-hydroxy-2,2-dimethyl-4-[[4-(pyridin-4-yloxy)phenyl]sulfonyl]thiomorpholine-3-carboxamide | - |
Homo sapiens | |
N-hydroxy-2,6-dimethoxy-3-[[(4-methoxyphenyl)sulfonyl](pyridin-3-ylmethyl)amino]pyridine-4-carboxamide | - |
Homo sapiens | |
N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](pyridin-3-ylmethyl)amino]-3-methylbenzamide | - |
Homo sapiens | |
N-hydroxy-3-methyl-2-(methyl[[4-(pyridin-4-yloxy)phenyl]sulfonyl]amino)benzamide | - |
Homo sapiens | |
N-hydroxy-4-([4-[(4-hydroxybut-2-yn-1-yl)oxy]phenyl]sulfonyl)-2,2-dimethylthiomorpholine-3-carboxamide | - |
Homo sapiens | |
N-hydroxy-N2-methyl-3-[(4-phenoxyphenyl)sulfonyl]-L-alaninamide | - |
Homo sapiens | |
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(pyridin-4-ylmethyl)valinamide | - |
Homo sapiens | |
N-[2-(4-[benzyl[2-(hydroxycarbamoyl)-4,6-dimethylphenyl]sulfamoyl]phenoxy)ethyl]-1-benzofuran-2-carboxamide | WAY-170523 | Homo sapiens | |
N-[3-(5-[[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]carbamoyl]furan-2-yl)benzyl]pyridine-2-carboxamide | - |
Homo sapiens | |
N-[4-(morpholin-4-yl)butyl]-1-benzofuran-2-carboxamide | i.e. CL-82198 | Homo sapiens | |
N-[[(3-phenyl-1,2-oxazol-5-yl)methyl]carbamothioyl]benzamide | competitive, is synergic with acetohydroxamic acid | Homo sapiens | |
N-[[4-(4-fluorophenoxy)phenyl]sulfonyl]-N-[1-(hydroxycarbamoyl)cyclopentyl]-b-alanine | - |
Homo sapiens | |
N2-[(2S)-2-[[(4-benzylbenzyl)(hydroxy)phosphoryl]methyl]-4-phenylbutanoyl]-N,3-dimethyl-L-valinamide | - |
Homo sapiens | |
N2-[(2S)-2-[[(4-benzylbenzyl)(hydroxy)phosphoryl]methyl]-6-phenoxyhexanoyl]-N,3-dimethyl-L-valinamide | - |
Homo sapiens | |
N2-[(4'-bromobiphenyl-4-yl)sulfonyl]-N-hydroxy-D-valinamide | - |
Homo sapiens | |
N2-[(4'-bromobiphenyl-4-yl)sulfonyl]-N-hydroxy-D-valinamide | a nonselective inhibitor | Rattus norvegicus | |
RS 102,481 | a small molecule preferential inhibitor of MMP13, the compound is able to potently inhibit the release of type II collagen degradation peptides from human osteoarthritis articular cartilage explants | Homo sapiens | |
RS 102,481 | a small molecule preferential inhibitor of MMP13 | Mus musculus | |
RS 102,481 | a small molecule preferential inhibitor of MMP13 | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus | |
Ca2+ | dependent on | Homo sapiens | |
Ca2+ | dependent on | Rattus norvegicus | |
Zn2+ | dependent on | Mus musculus | |
Zn2+ | dependent on | Homo sapiens | |
Zn2+ | dependent on | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Mus musculus | - |
? | - |
? | |
Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
Gelatin + H2O | Rattus norvegicus | high activity | ? | - |
? | |
additional information | Rattus norvegicus | rat MMP13 is a better gelatinase than a collagenase. Injection of catalytically active recombinant MMP13 enzyme into a rat knee joint to induce cartilage damage | ? | - |
? | |
Type I collagen + H2O | Mus musculus | fibrillar type | ? | - |
? | |
Type I collagen + H2O | Homo sapiens | fibrillar type | ? | - |
? | |
Type I collagen + H2O | Rattus norvegicus | fibrillar type | ? | - |
? | |
type II collagen + H2O | Mus musculus | fibrillar type | ? | - |
? | |
type II collagen + H2O | Homo sapiens | fibrillar type | ? | - |
? | |
type II collagen + H2O | Rattus norvegicus | fibrillar type | ? | - |
? | |
type III collagen + H2O | Mus musculus | fibrillar type | ? | - |
? | |
type III collagen + H2O | Homo sapiens | fibrillar type | ? | - |
? | |
type III collagen + H2O | Rattus norvegicus | fibrillar type | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
bone | mRNA encoding MMP13 is present in multiple cell types involved in human fetal bone development | Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
cartilage | - |
Mus musculus | - |
cartilage | articular, from osteoarthritis and rheumatoid arthritis patients | Homo sapiens | - |
chondrocyte | - |
Mus musculus | - |
chondrocyte | - |
Homo sapiens | - |
head and neck squamous cell carcinoma cell line | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
salivary gland cancer cell | - |
Homo sapiens | - |
skin cancer cell | high levels of MMP13 mRNA only in malignant squamous epithelium of the skin, while premalignant and benign tumors are mostly negative for MMP13 | Homo sapiens | - |
synovial membrane | expression of MMP13 in the synovial membrane of patients with rheumatoid and osteoarthritis | Homo sapiens | - |
synovial tissue | high expression of MMP13 in rheumatoid arthritis synovial tissue | Homo sapiens | - |
uterus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-PLG(S)LLG-OEt thioester + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Gelatin + H2O | high activity | Rattus norvegicus | ? | - |
? | |
additional information | rat MMP13 is a better gelatinase than a collagenase. Injection of catalytically active recombinant MMP13 enzyme into a rat knee joint to induce cartilage damage | Rattus norvegicus | ? | - |
? | |
Type I collagen + H2O | fibrillar type | Mus musculus | ? | - |
? | |
Type I collagen + H2O | fibrillar type | Homo sapiens | ? | - |
? | |
Type I collagen + H2O | fibrillar type | Rattus norvegicus | ? | - |
? | |
type II collagen + H2O | fibrillar type | Mus musculus | ? | - |
? | |
type II collagen + H2O | fibrillar type | Homo sapiens | ? | - |
? | |
type II collagen + H2O | fibrillar type | Rattus norvegicus | ? | - |
? | |
type III collagen + H2O | fibrillar type | Mus musculus | ? | - |
? | |
type III collagen + H2O | fibrillar type | Homo sapiens | ? | - |
? | |
type III collagen + H2O | fibrillar type | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
collagenase-3 | - |
Homo sapiens |
collagenase-3 | - |
Rattus norvegicus |
MMP13 | - |
Mus musculus |
MMP13 | - |
Homo sapiens |
MMP13 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | steady-state inhibition kinetics studies | Homo sapiens | |
0.00000003 | - |
N-hydroxy-2,2-dimethyl-4-[[4-(pyridin-4-yloxy)phenyl]sulfonyl]thiomorpholine-3-carboxamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000000016 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[[(4'-chlorobiphenyl-4-yl)oxy]methyl]-N-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanamide | |
0.00000008 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[[[4-(4-chlorophenoxy)phenyl]sulfonyl](methyl)amino]-N-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzamide | |
0.0000002 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[[(4'-cyanobiphenyl-4-yl)oxy]methyl]-N-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanamide | |
0.00000033 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-(4-phenoxyphenyl)-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone | |
0.00000036 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-(6-[4-[4-(4-fluorophenyl)-1,3-oxazol-2-yl]phenoxy]pyridin-3-yl)-1,7,9-triazaspiro[4.5]decane-6,8,10-trione | |
0.00000036 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-[2-[4-(4-[[5-(2-ethoxyethyl)-2,4,6-trioxohexahydropyrimidin-5-yl]oxy]phenoxy)phenyl]-1,3-oxazol-4-yl]benzonitrile | |
0.0000004 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-methyl-3-[(4-phenoxyphenyl)sulfonyl]-L-alaninamide | |
0.0000005 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-([[4-(4-fluorophenoxy)phenyl]sulfonyl]amino)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | |
0.00000067 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-[[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl]benzoic acid | |
0.00000075 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-([[4-(4-fluorophenoxy)phenyl]sulfonyl]amino)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | |
0.0000009 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1,5-anhydro-2,3-dideoxy-3-[[4-(2,4-dichlorophenoxy)phenyl]sulfonyl]-4-C-(hydroxycarbamoyl)-D-threo-pentitol | |
0.0000009 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-[[4-(4-fluorophenoxy)phenyl]sulfonyl]-N-[1-(hydroxycarbamoyl)cyclopentyl]-b-alanine | |
0.00000095 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2R,3R)-4-[[4-(2-chloro-4-fluorophenoxy)phenyl]sulfonyl]-N,2-dihydroxy-2-methylmorpholine-3-carboxamide | |
0.0000013 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-([4'-[(1-benzofuran-2-ylcarbonyl)amino]biphenyl-4-yl]sulfonyl)valine | |
0.00000154 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-[[4-oxo-6-(3-phenylprop-1-yn-1-yl)quinazolin-3(4H)-yl]methyl]benzoic acid | |
0.0000018 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[[(4'-[[(5-bromo-4-methoxy-3-methyl-1-benzofuran-2-yl)carbonyl]amino]biphenyl-4-yl)sulfonyl]methyl]-3-methylbutanoic acid | |
0.000003 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2S,3R)-1-acetyl-N-hydroxy-2-methyl-4-[[4-(2-methylbenzyl)phenyl]sulfonyl]piperidine-3-carboxamide | |
0.000003 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4R)-1-[4-(4-fluorophenoxy)benzyl]-N-hydroxy-2-oxoimidazolidine-4-carboxamide | |
0.000004 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-hydroxy-3-methyl-2-(methyl[[4-(pyridin-4-yloxy)phenyl]sulfonyl]amino)benzamide | |
0.0000045 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(ethyl[[4-(prop-1-yn-1-yloxy)phenyl]sulfonyl]amino)-5-phenylpentane(thioperox)ic O-acid | |
0.0000066 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide | |
0.00000672 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-([6-[(4-methoxybenzyl)carbamoyl]-4-oxopyrido[3,4-d]pyrimidin-3(4H)-yl]methyl)benzoic acid | |
0.000007 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4S)-4-[4-(4-fluorophenoxy)phenyl]-N-hydroxy-5-oxo-D-prolinamide | |
0.000008 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide | |
0.000008 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-hydroxy-4-([4-[(4-hydroxybut-2-yn-1-yl)oxy]phenyl]sulfonyl)-2,2-dimethylthiomorpholine-3-carboxamide | |
0.000008 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](pyridin-3-ylmethyl)amino]-3-methylbenzamide | |
0.00001 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-(2-ethoxyethyl)-5-[4-[4-(1,3,4-oxadiazol-2-yl)phenoxy]phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.0000122 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-fluoro-N-hydroxy-6-([4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]sulfonyl)benzamide | |
0.000014 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N2-[(2S)-2-[[(4-benzylbenzyl)(hydroxy)phosphoryl]methyl]-4-phenylbutanoyl]-N,3-dimethyl-L-valinamide | |
0.0000149 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-([4'-[([4-[(2-carboxypropan-2-yl)oxy]-1-benzofuran-2-yl]carbonyl)amino]biphenyl-4-yl]sulfonyl)-L-valine | |
0.000015 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3,5-dimethylbenzamide | |
0.000017 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-[2-(4-[benzyl[2-(hydroxycarbamoyl)-4,6-dimethylphenyl]sulfamoyl]phenoxy)ethyl]-1-benzofuran-2-carboxamide | |
0.000021 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N2-[(2S)-2-[[(4-benzylbenzyl)(hydroxy)phosphoryl]methyl]-6-phenoxyhexanoyl]-N,3-dimethyl-L-valinamide | |
0.00003 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | benzyl 6-benzyl-5,7-dioxo-6,7-dihydro-5H-[1,3]thiazolo[3,2-c]pyrimidine-2-carboxylate | |
0.000047 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-hydroxy-2,6-dimethoxy-3-[[(4-methoxyphenyl)sulfonyl](pyridin-3-ylmethyl)amino]pyridine-4-carboxamide | |
0.000065 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-methyl-5-(4-phenoxyphenoxy)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.000078 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-hexyl-5-(4-phenoxyphenoxy)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.00039 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-(4-chlorophenoxy)-5-methylpyrimidine-2,4,6(1H,3H,5H)-trione | |
0.01 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-[4-(morpholin-4-yl)butyl]-1-benzofuran-2-carboxamide |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | strong stimulus of a combination of interleukin-1alpha plus oncostatin M, inducing MMP13 expression | up |
General Information | Comment | Organism |
---|---|---|
additional information | cartilage structural damage in osteoarthritis in mice is dependent on MMP13 activity | Mus musculus |
additional information | high MMP13 expression is correlated with poor prognosis and reduced median overall survival in patients with head and neck cancer. High MMP13 levels in patients with salivary gland cancer are also associated with poor survival. And high levels of tumor-derived MMP13 correlate with poor prognosis in invasive breast cancer and reduced overall survival | Homo sapiens |
physiological function | MMP13 plays a critical role in the redifferentiation phase of kidney development. Potential role of MMP13 in endochondral and intramembranous ossification, with a functional role in skeletal development. MMP13 plays a significant role in the cartilage collagen degradation that occurs in osteoarthritis, and a pathological role of the degradative MMP13 enzyme in rheumatoid arthritis. The catalytic activity of MMP13 may play a role in the high invasion capacity of these cancer cells. Degradation of basement membrane is thought to be an early and critical event influencing tumor invasion and metastasis. MMP13 plays a role in proteolytic activity in invasive malignant growth | Homo sapiens |
physiological function | the MMP-13 knockout phenotype, which is due to an inability of chondrocytes to exit the growth plate, resolves completely by 12 weeks of age, suggesting that other (collagen degrading) proteases can at least partially functionally substitute for MMP13 in this developmental role | Mus musculus |