Literature summary for 3.4.24.B4 extracted from

Tan, T.W.; Lai, C.H.; Huang, C.Y.; Yang, W.H.; Chen, H.T.; Hsu, H.C.; Fong, Y.C.; Tang, C.H.
CTGF enhances migration and MMP-13 up-regulation via alphanybeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells (2009), J. Cell. Biochem., 107, 345-356.

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Cloned(Commentary)

Cloned (Comment)	Organism
quantitative real-time PCR MMP-13 expression analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrosarcoma cell	-	Homo sapiens	-
commercial preparation	-	Homo sapiens	-
JJ012 cell	-	Homo sapiens	-
additional information	quantitative real-time PCR MMP-13 expression analysis	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	connective tissue growth factor, CTGF, a secreted protein that binds to integrins, increases the migration and expression of MMP-13 in chondrosarcoma JJ012 cells through the alphanybeta3 integrin, FAK, ERK, and NF-kappaB signal transduction pathway. The induction is inhibited by MAPK kinase inhibitors PD98059 and U0126, but not by RAD peptide. Also treatment of JJ012 cells with NF-kappaB inhibitor PDTC or IkappaB protease inhibitor TPCK inhibits CTGF-induced cell migration and MMP-13 up-regulation, overview	up

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Release 2023.1 (January 2023)