Protein Variants | Comment | Organism |
---|---|---|
additional information | MMP-13 downregulation by siRNA | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens | |
Zn2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Homo sapiens | - |
U-251 cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bovine type B gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | GDNF-induced MMP-13 expression and glioma migration are attenuated by MEK/extracellular signal-regulating kinase and c-Jun N-terminal protein kinase inhibitors, PD98059 and SP600125, as well as ERK and JNKdominant-negative mutants. AP-1 inhibitors, tanshinone IIA and curcumin, also reduce GDNF-induced glioma cell migration | additional information |
Homo sapiens | glial cell line-derived neurotrophic factor, GDNF, induces cell migration and MMP-13 expression in glioma cells | up |