Literature summary for 3.4.24.B4 extracted from

Engel, C.K.; Pirard, B.; Schimanski, S.; Kirsch, R.; Habermann, J.; Klingler, O.; Schlotte, V.; Weithmann, K.U.; Wendt, K.U.
Structural basis for the highly selective inhibition of MMP-13 (2005), Chem. Biol., 12, 181-189.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme catalytic domain in complex with inhibitor N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide, N,N'-bis(3-methylbenzyl)pyrimidine-4,6-dicarboxamide or N,N'-bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
N,N'-bis(3-methylbenzyl)pyrimidine-4,6-dicarboxamide	50% inhibition at 72 nM	Homo sapiens
N,N'-bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide	50% inhibition at 8 nM	Homo sapiens
N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide	50% inhibition at 6600 nM	Homo sapiens
N,N'-dibenzylpyrimidine-4,6-dicarboxamide	50% inhibition at 400 nM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P45452	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	rheumatoid synovial fibroblast	Homo sapiens	-

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Release 2023.1 (January 2023)