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Literature summary for 3.4.24.B4 extracted from

  • Kim, S.H.; Pudzianowski, A.T.; Leavitt, K.J.; Barbosa, J.; McDonnell, P.A.; Metzler, W.J.; Rankin, B.M.; Liu, R.; Vaccaro, W.; Pitts, W.
    Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) (2005), Bioorg. Med. Chem. Lett., 15, 1101-1106.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Application

Application Comment Organism
medicine selective inhibitors for enzyme for potential use in treatment of osteoarthritis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(4-phenoxyphenyl)-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone comparison of selectivity with other matrix metalloproteinases Homo sapiens
1-[4-((4-phenoxy)phenoxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone comparison of selectivity with other matrix metalloproteinases Homo sapiens
1-[4-(1,3-benzodioxol-5-yloxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone comparison of selectivity with other matrix metalloproteinases Homo sapiens
1-[4-(3-methoxyphenoxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone comparison of selectivity with other matrix metalloproteinases Homo sapiens
1-[4-(4-chlorophenoxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone comparison of selectivity with other matrix metalloproteinases Homo sapiens
4-[4-(2,6,8,10-tetraoxo-1,7,9-triazaspiro[4.5]dec-1-yl)phenoxy]benzoic acid comparison of selectivity with other matrix metalloproteinases Homo sapiens
methyl 4-[4-(2,6,8,10-tetraoxo-1,7,9-triazaspiro[4.5]dec-1-yl)phenoxy]benzoate comparison of selectivity with other matrix metalloproteinases Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000033
-
 1-[4-((4-phenoxy)phenoxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone
-
 Homo sapiens
0.00000095
-
 1-[4-(4-chlorophenoxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone
-
 Homo sapiens
0.0000019
-
 1-[4-(3-methoxyphenoxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone
-
 Homo sapiens
0.0000027
-
 4-[4-(2,6,8,10-tetraoxo-1,7,9-triazaspiro[4.5]dec-1-yl)phenoxy]benzoic acid
-
 Homo sapiens
0.0000042
-
 methyl 4-[4-(2,6,8,10-tetraoxo-1,7,9-triazaspiro[4.5]dec-1-yl)phenoxy]benzoate
-
 Homo sapiens
0.0000047
-
 1-(4-phenoxyphenyl)-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone
-
 Homo sapiens
0.0000058
-
 1-[4-(1,3-benzodioxol-5-yloxy)phenyl]-1,7,9-triazaspiro[4.5]decane-2,6,8,10-tetrone
-
 Homo sapiens