Cloned (Comment) | Organism |
---|---|
gene MMP11, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | pEnter-MMP-11 plasmid, and MMP-11 small interfering RNA are applied to up- and downregulate MMP-11 expression of in cultured papillary thyroid carcinoma (PTC) cell lines K1 and BCPAP | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular matrix | - |
Homo sapiens | 31012 | - |
intracellular | - |
Homo sapiens | 5622 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc-dependent endopeptidase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P24347 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-CPAP cell | - |
Homo sapiens | - |
K1 cell | - |
Homo sapiens | - |
papillary thyroid cancer cell | usage of microarray analysis to compare the variations of gene expression within the papillary thyroid carcinoma (PTC) cell populations and their adjacent normal tissues, MMP-11 is the most differentially expressed matrix metalloproteinase, MMP. MMP-11 expression is upregulated in PTC. The change in cyclin D1 is consistent with MMP-11 expression, which may explain the changes in proliferation | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-11 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | MMP-11 expression is upregulated in papillary thyroid carcinoma | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the levels of proliferation and migration of cells transfected with MMP-11 siRNA are significantly reduced, while the levels in MMP-11-plasmid-transfected cells are increased. Variations in intracellular MMP-11 significantly alters the amount of phospho-p65 in thyroid cells, while p65 knockdown does not affect MMP-11 expression | Homo sapiens |
metabolism | MMP-11 regulatory migration is associated with the NF-kappaB p65 signaling pathway | Homo sapiens |
physiological function | matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that digest the intercellular matrix, thereby affecting the tumor microenvironment by promoting angiogenesis, tumor growth, and metastasis. Role of MMP-11 in the mediation of thyroid cancer cell development, as well as in regulation of thyroid cell proliferation and migration. MMP-11 is the most differentially expressed matrix metalloproteinase, MMP. The change in cyclin D1 is consistent with MMP-11 expression, which may explain the changes in proliferation. MMP-11 is located upstream of p65 and regulates its activity. MMP-11 regulatory migration is also associated with the NF-kappaB p65 signaling pathway. MMP-11 promotes activation of p65 | Homo sapiens |