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Literature summary for 3.4.24.B3 extracted from
- Purification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors (1999), Protein Expr. Purif., 16, 76-83.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of the catalytic domain in Escherichia coli BL21(DE3) | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Mus musculus |  |
| cephalosporin EK2900 | - |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein + H2O | Mus musculus | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant catalytic domain expressed in Escherichia coli with a recovery of 7% | Mus musculus |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| solubilization and refolding of recombinant catalytic enzyme domain from inclusion bodies after expression in Escherichia coli | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Ala-S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-N3-(2,4-dinitrophenyl)-L-2,3-diamino propionylamide + H2O | - |
Mus musculus | (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Ala + S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-N3-(2,4-dinitrophenyl)-L-2,3-diamino propionylamide | - |
? | |
| alpha1-protease inhibitor + H2O | - |
Mus musculus | ? | - |
? | |
| additional information | no efficient cleavage of matrixin substrate Mca-Pro-Leu-Ala-Leu-Dpa-Ala-Arg-NH2 | Mus musculus | ? | - |
? | |
| protein + H2O | - |
Mus musculus | peptides | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M10.007 | Merops-ID | Mus musculus |
| matrix metalloproteinase-11 | - |
Mus musculus |
| MMP-11 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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