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Literature summary for 3.4.24.B3 extracted from

  • Gall, A.L.; Ruff, M.; Kannan, R.; Cuniasse, P.; Yiotakis, A.; Dive, V.; Rio, M.C.; Basset, P.; Moras, D.
    Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state (2001), J. Mol. Biol., 307, 577-586.
    View publication on PubMed
Search for more literature for 3.4.24.B3

Cloned(Commentary)

Cloned (Comment) Organism
expression of catalytic domain connected to the hemopexin-like domain in Escherichia coli BL21(DE3) Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
catalytic domain complexed with a phosphinic inhibitor mimicking the transition state, hanging drop method, 5 mg/ml protein in 0.05 M MES, pH 5.5, 0.5 M ammonium sulfate, 1% v/v trifluoroethanol, 4°C, a few months, X-ray diffraction structure determination at 2.6 A resolution and analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phosphinic inhibitor inhibitor binding mechanism Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc 3 zinc atoms per enzyme molecule, metalloproteinase, the zinc binding site is catalytically active Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Mus musculus
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q02853 precursor
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins mechanism Mus musculus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein + H2O
-
 Mus musculus peptides
-
 ?

Synonyms

Synonyms Comment Organism
M10.007 Merops-ID Mus musculus
matrix metalloproteinase-11
-
 Mus musculus
MMP-11
-
 Mus musculus
SL-3
-
 Mus musculus
ST3
-
 Mus musculus