Literature summary for 3.4.24.B3 extracted from

Manes, S.; Mira, E.; Barbacid, M.M.; Cipres, A.; Fernandez-Resa, P.; Buesa, J.M.; Merida, I.; Aracil, M.; Marquez, G.; Martinez, A.C.
Identification of insulin-like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3 (1997), J. Biol. Chem., 272, 25706-25712.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in MCF-7 breat adenocarcinoma cells, secretion of the enzyme	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
matrix metalloproteinase inhibitor BB-94	-	Homo sapiens
matrix metalloproteinase inhibitor TIMP-2	-	Homo sapiens
additional information	no inhibition by aprotinin	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
60000	-	x * 60000, procesed enzyme, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protein + H2O	Homo sapiens	enzyme plays a role in tumor progression and wound healing	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	autoproteiolytic processing	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
insulin-like growth factor-binding protein-1 + H2O	specific for, cleavage site is the His140-Val141 bond	Homo sapiens	2 peptides of 16 and 9 kDa MW	-	?
additional information	no activity with casein or gelatin	Homo sapiens	?	-	?
protein + H2O	-	Homo sapiens	peptides	-	?
protein + H2O	enzyme plays a role in tumor progression and wound healing	Homo sapiens	peptides	-	?

Subunits

Subunits	Comment	Organism
?	x * 60000, procesed enzyme, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
M10.007	Merops-ID	Homo sapiens
matrix metalloproteinase-11	-	Homo sapiens
MMP-11	-	Homo sapiens
ST-3	-	Homo sapiens

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Release 2023.1 (January 2023)