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Literature summary for 3.4.24.B17 extracted from

  • Herman, C.; Thevenet, D.; Bouloc, P.; Walker, G.C.; D'Ari, R.
    Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH) (1998), Genes Dev., 12, 1348-1355.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant from plasmid Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information enzyme mutant still shows activity with substrates derivative of the N-terminal domain of the lambdacI repressor tagged with cI105 and SsrA Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral, with the active site in the cytoplasm Escherichia coli 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc protease Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Escherichia coli tail specific pathway for removing abnormal cytoplasmic proteins via the enzyme, disposition by degradation of polypeptides synthesized from truncated mRNA molecules and are C-terminally tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10Sa stable RNA peptides
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AAI3 K12 derivatives, strain JM105
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme shows overlapping substrate specificity with the proteases C1pXP and C1pAP, the enzymes can compensate for each other in degrading the c1-SsrA tagged substrate protein Escherichia coli ?
-
?
protein + H2O
-
Escherichia coli peptides
-
?
protein + H2O tail specific pathway for removing abnormal cytoplasmic proteins via the enzyme, disposition by degradation of polypeptides synthesized from truncated mRNA molecules and are C-terminally tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10Sa stable RNA Escherichia coli peptides
-
?
protein lambdaCII + H2O regulatory protein Escherichia coli ?
-
?
protein lambdaCIII + H2O regulatory protein Escherichia coli ?
-
?
protein sigma32 + H2O heat shock factor Escherichia coli ?
-
?
unstable derivatives of the N-terminal domain of the lambdacI repressor + H2O 3 derivatives with a nonpolar pentapeptide tail, i.e. cI104, cI105, cI108, and 1 with the SsrAtag, i.e. cI-SsrA Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
cell division protein ftsH
-
Escherichia coli
FtsH
-
Escherichia coli
FTSH_ECOLI
-
Escherichia coli
HflB
-
Escherichia coli
M41.001 Merops-ID Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Escherichia coli