Literature summary for 3.4.24.B16 extracted from

Grande, K.K.; Gustin, J.K.; Kessler, E.; Ohman, D.E.
Identification of critical residues in the propeptide of LasA protease of Pseudomonas aeruginosa involved in the formation of a stable mature protease (2007), J. Bacteriol., 189, 3960-3968.

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Protein Variants

Protein Variants	Comment	Organism
G115A	slightly reduced activity	Pseudomonas aeruginosa
H94A	mutation is moderately unstable and allows the production of a LasA protein with low enzymatic activity	Pseudomonas aeruginosa
I101A	mutation is moderately unstable and allows the production of a LasA protein with low enzymatic activity	Pseudomonas aeruginosa
L92A	mutation results in highly unstable protein that is susceptible to proteolytic degradation	Pseudomonas aeruginosa
N102A	mutation is moderately unstable and allows the production of a LasA protein with low enzymatic activity	Pseudomonas aeruginosa
W95A	mutation results in highly unstable protein that is susceptible to proteolytic degradation	Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
20000	-	mature enzyme, SDS-PAGE	Pseudomonas aeruginosa
42000	-	SDS-PAGE, LasA is synthesized as a preproenzyme that undergoes proteolysis to remove a 22000 Da amino-terminal propeptide	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	staphylolytic activity is pentaglycine in the peptidoglycan of Staphylococcus aureus	Pseudomonas aeruginosa	?	-	?

Synonyms

Synonyms	Comment	Organism
LasA endopeptidase	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)