Any feedback?
Literature summary for 3.4.24.B16 extracted from
- Elastase and the LasA protease of Pseudomonas aeruginosa are secreted with their propeptides (1998), J. Biol. Chem., 273, 30225-30231.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Pseudomonas aeruginosa | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20000 | - |
x * 20000, LasA, SDS-PAGE, x * 42000, proLasA, SDS-PAGE | Pseudomonas aeruginosa |
| 42000 | - |
x * 20000, LasA, SDS-PAGE, x * 42000, proLasA, SDS-PAGE | Pseudomonas aeruginosa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein + H2O | Pseudomonas aeruginosa | - |
peptides | - |
? |  |
| protein + H2O | Pseudomonas aeruginosa FRD740 | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
| Pseudomonas aeruginosa FRD740 | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | no autoproteolysis, enzyme is synthesized as a pre-proLasA, the signal sequence of pre-proLasA is cleaved off by a signal peptidase, the remaining inactive 42 kDa proLasA is secreted to the extracellular space, where the proform is cleaved to the mature active enzyme via a 28 kDa intermediate, plus a 14 kDa fragment, by elastase and a lysine specific protease, not by alkaline proteinase | Pseudomonas aeruginosa |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from culture supernatant | Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein + H2O | - |
Pseudomonas aeruginosa | peptides | - |
? | |
| protein + H2O | - |
Pseudomonas aeruginosa FRD740 | peptides | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 20000, LasA, SDS-PAGE, x * 42000, proLasA, SDS-PAGE | Pseudomonas aeruginosa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M23.002 | Merops-ID | Pseudomonas aeruginosa |
| staphylolysin | - |
Pseudomonas aeruginosa |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
