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Literature summary for 3.4.24.B16 extracted from
- Purification and characterization of an active fragment of the LasA protein from Pseudomonas aeruginosa: enhancement of elastase activity (1990), J. Bacteriol., 172, 2236-2240.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Pseudomonas aeruginosa | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22000 | - |
x * 22000, SDS-PAGE | Pseudomonas aeruginosa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Pseudomonas aeruginosa | enzyme activates elastase, and the elastolytic activity of thermolysin, human neutrophil elastase, proteinase K, by interacting with the elastin substrate rather than the other enzyme | ? | - |
? |  |
| protein + H2O | Pseudomonas aeruginosa | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | enzyme precursor contains an elastase cleavage motif at the N-terminus, the enzyme is probably activated by elastase to activate the elastase afterwards | Pseudomonas aeruginosa |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pseudomonas aeruginosa |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme activates elastase, and the elastolytic activity of thermolysin, human neutrophil elastase, proteinase K, by interacting with the elastin substrate rather than the other enzyme | Pseudomonas aeruginosa | ? | - |
? | |
| protein + H2O | - |
Pseudomonas aeruginosa | peptides | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 22000, SDS-PAGE | Pseudomonas aeruginosa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LasA | - |
Pseudomonas aeruginosa |
| M23.002 | Merops-ID | Pseudomonas aeruginosa |
| staphylolysin | - |
Pseudomonas aeruginosa |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Pseudomonas aeruginosa | above, isoelectric focussing | - |
9.5 |
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