Literature summary for 3.4.24.B14 extracted from

Oh-Hashi, K.; Ohkubo, K.; Shizu, K.; Fukuda, H.; Hirata, Y.; Kiuchi, K.
Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2 (2008), Mol. Cell. Biochem., 313, 103-111.

Search for more literature for 3.4.24.B14

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK293 cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
calcium ionophore A23187	0.001 mM	Mus musculus
forskolin	0.01 mM	Mus musculus
additional information	disruption of the Golgi apparatus with brefeldin A markedly reduces extracellular NEP2 activity in parallel with intracellular NEP2 protein level in HEK293 cells; nocodazole and cytochalasin B barely affect NEP2 activity	Mus musculus
thapsigargin	0.0001 mM	Mus musculus
tunicamycin	inhibition of N-glycosylation by tunicamycin reduces the enzymatic activity of extracellular NEP2 to about 50% and the molecular size of intracellular NEP2	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	-	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	does not cleave dansyl-D-Ala-Gly-p-nitro-Phe-Gly	Mus musculus	?	-	?
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O	-	Mus musculus	succinyl-Ala-Ala + Phe-7-amido-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
NEP2	-	Mus musculus
neprilysin 2	-	Mus musculus
NL-1	-	Mus musculus
SEP	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)