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Literature summary for 3.4.24.B12 extracted from

  • Verma, P.; Dalal, K.
    ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis (2011), J. Cell. Biochem., 112, 3507-3514.
    View publication on PubMed
Search for more literature for 3.4.24.B12

Activating Compound

Activating Compound Comment Organism Structure
NaCl optimum concentration for aggrecan degradation is 200 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O
-
 Homo sapiens ?
-
 ?
alpha2-macroglobulin + H2O
-
 Homo sapiens ?
-
 ?
brevican + H2O
-
 Homo sapiens ?
-
 ?
additional information ADAMTS-5 shows proteolytic activity by second TS domain and little by catalytic domain alone and exhibits 1000fold greater strength of proteolytic activities as compared to ADAMTS-4 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-11
-
 Homo sapiens
ADAMTS-5
-
 Homo sapiens
aggrecanase-2
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 9.5
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ADAMTS-5 expression is not regulated by interleukin-1 and tumor necrosis factor-alpha additional information

General Information

General Information Comment Organism
malfunction ADAMTS-5 knockout mice express no major phenotypical abnormalities, but show a significant reduction in the severity of surgically induced osteoarthritis in the ADAMTS-5 in contrast to the ADAMTS-4 knockout groups Homo sapiens
physiological function ADAMTS-5 contributes to the structural damage of cartilage that characterizes human osteoarthritis Homo sapiens